- Senior Investigator, Section on Nutrient Control of Gene Expression
Dr. Alan G. Hinnebusch received his B.S. in Biology from the University of Dayton, Ohio, in 1975 and his Ph.D. in Biochemistry and Molecular Biology from Harvard University in 1980. He studied as a postdoctoral fellow in the laboratory of Dr. Gerald R. Fink at Cornell University and the Massachusetts Institute of Technology from 1980 to 1983. He joined the NICHD as a Senior Staff Fellow in 1983 and became Chief of the Laboratory of Eukaryotic Gene Regulation in 1995. In 2000, he was appointed as Chief of the Laboratory of Gene Regulation and Development and Head of the Section on Nutrient Control of Gene Regulation. In 2007, he was named Head of the Program in Cellular Regulation and Metabolism. Dr. Hinnebusch has served on the editorial boards of Genetics, Microbiological Reviews, Molecular Microbiology, Journal of Biological Chemistry, and is currently a member of the editorial boards of Genes & Development and Molecular & Cellular Biology. He was co-organizer of the Cold Spring Harbor Laboratory Meeting on Translational Control from 2000 to 2010. He has published more than 170 research articles in peer-reviewed journals and more than 30 review articles and book chapters pertaining to his field of research. In 1994 he was named Maryland's Outstanding Young Scientist and was elected as a Fellow of the American Academy of Microbiology. In 2009 he was elected as a Fellow of the American Association for the Advancement of Science and as a Fellow of the American Academy of Arts and Sciences.
Academic Articles260
- (2020). Chromatin remodeler Ino80C acts independently of H2A.Z to evict promoter nucleosomes and stimulate transcription of highly expressed genes in yeast. NUCLEIC ACIDS RESEARCH. 48(15), 8408-8430.
- (2020). Selective Translation Complex Profiling Reveals Staged Initiation and Co-translational Assembly of Initiation Factor Complexes. MOLECULAR CELL. 79(4), 546-+.
- (2020). elF1 discriminates against suboptimal initiation sites to prevent excessive uORF translation genome-wide. RNA. 26(4), 419-438.
- (2019). A network of eIF2 interactions with eIF1 and Met-tRNA(i) promotes accurate start codon selection by the translation preinitiation complex. NUCLEIC ACIDS RESEARCH. 47(5), 2574-2593.