Scholars

Senior Investigator

Positions:

Senior Investigator, Laboratory of Genome Integrity

overview

Avinash Bhandoola received a Ph.D. from the University of Pennsylvania in 1994, and did a postdoctoral fellowship with Dr. Alfred Singer at NCI focused on the rules underlying lineage choice. He joined the faculty of the University of Pennsylvania in 2001, received tenure in 2007, and was promoted to full professor in 2012. He subsequently joined the Laboratory of Genome Integrity in 2014.

selected publications

Academic Articles110

(2020). Postnatal Involution and Counter-Involution of the Thymus. Frontiers in Immunology. 11,
(2020). A Shared Regulatory Element Controls the Initiation of Tcf7 Expression During Early T Cell and Innate Lymphoid Cell Developments. Frontiers in Immunology. 11,
(2020). Single-cell analysis of ROR alpha tracer mouse lung reveals ILC progenitors and effector ILC2 subsets. JOURNAL OF EXPERIMENTAL MEDICINE. 217(3),
(2020). Switch hitter: Bcl11b in T cells and ILC2s. JOURNAL OF EXPERIMENTAL MEDICINE. 217(1),
(2019). Blocked O-GlcNAc cycling disrupts mouse hematopoeitic stem cell maintenance and early T cell development. Scientific Reports. 9,
(2019). Cutting Edge: Core Binding Factor beta Is Required for Group 2 Innate Lymphoid Cell Activation. JOURNAL OF IMMUNOLOGY. 202(6), 1669-1673.
(2019). Dominant activating RAC2 mutation with lymphopenia, immunodeficiency, and cytoskeletal defects. BLOOD. 133(18), 1977-1988.
(2019). Heterozygous FOXN1 Variants Cause Low TRECs and Severe T Cell Lymphopenia, Revealing a Crucial Role of FOXN1 in Supporting Early Thymopoiesis. AMERICAN JOURNAL OF HUMAN GENETICS. 105(3), 549-561.
(2019). Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells. JOURNAL OF IMMUNOLOGY. 203(3), 686-695.
(2019). MAIT cells are imprinted by the microbiota in early life and promote tissue repair. SCIENCE. 366(6464), 445-+.
(2019). Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth. Nature Communications. 10,
(2019). Response to Comment on "Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells". JOURNAL OF IMMUNOLOGY. 203(9), 2355-2356.
(2019). TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8(+) T cell exhaustion. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 116(25), 12410-12415.
(2019). The PLOS Biology XV Collection: 15 Years of Exceptional Science Highlighted across 12 Months. 17(2),
(2019). The transcription factor c-Myb regulates CD8(+) T cell stemness and antitumor immunity. NATURE IMMUNOLOGY. 20(3), 337-+.
(2018). Development and differentiation of early innate lymphoid progenitors. JOURNAL OF EXPERIMENTAL MEDICINE. 215(1), 249-262.
(2018). Lineage specification in innate lymphocytes. CYTOKINE & GROWTH FACTOR REVIEWS. 42, 20-26.
(2018). Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells. IMMUNITY. 48(2), 243-+.
(2017). CD4(+) T cell effector commitment coupled to self-renewal by asymmetric cell divisions. JOURNAL OF EXPERIMENTAL MEDICINE. 214(1), 39-47.
(2017). Cutting Edge: Notch Signaling Promotes the Plasticity of Group-2 Innate Lymphoid Cells. JOURNAL OF IMMUNOLOGY. 198(5), 1798-1803.
(2017). T cell progenitor therapy-facilitated thymopoiesis depends upon thymic input and continued thymic microenvironment interaction. JCI Insight. 2(10),
(2016). A doppelganger of T cell development. CELL CYCLE. 15(4), 479-480.
(2016). CD8(+) T Lymphocyte Self-Renewal during Effector Cell Determination. Cell Reports. 17(7), 1773-1782.
(2016). Coreceptor Reversal in the Thymus: Signaled CD4(+)8(+) Thymocytes Initially Terminate CD8 Transcription Even When Differentiating into CD8(+) T Cells. JOURNAL OF IMMUNOLOGY. 196(5), 1985-1997.
(2016). Group 2 innate lymphoid cells mediate ozone-induced airway inflammation and hyperresponsiveness in mice. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 137(2), 571-578.
(2016). Intrathymic Injection. 1323, 203-209.
(2016). Progress on thymic function from Maui. NATURE IMMUNOLOGY. 17(10), 1129-1132.
(2016). Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML. Science Signaling. 9(445),
(2016). The development of adult innate lymphoid cells. CURRENT OPINION IN IMMUNOLOGY. 39, 114-120.
(2015). Editorial: Ephs, ephrins, and early T cell development. JOURNAL OF LEUKOCYTE BIOLOGY. 98(6), 877-879.
(2015). TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow. NATURE IMMUNOLOGY. 16(10), 1044-+.
(2015). Transcription Factor Bcl11b Controls Identity and Function of Mature Type 2 Innate Lymphoid Cells. IMMUNITY. 43(2), 354-368.
(2015). Transcriptional Regulation of Innate and Adaptive Lymphocyte Lineages. Annual Review of Immunology. 33, 607-642.
(2014). Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity. SCIENCE. 343(6169), 432-437.
(2014). Chemokine treatment rescues profound T-lineage progenitor homing defect after bone marrow transplant conditioning in mice. BLOOD. 124(2), 296-304.
(2014). The microRNA Biogenesis Machinery Modulates Lineage Commitment during alpha beta T Cell Development. JOURNAL OF IMMUNOLOGY. 193(8), 4032-4042.
(2014). Trafficking to the Thymus. Current Topics in Microbiology and Immunology. 373, 87-111.
(2013). Deconstructing development. NATURE IMMUNOLOGY. 14(6), 529-531.
(2013). Early T-cell progenitors are the major granulocyte precursors in the adult mouse thymus. BLOOD. 121(1), 64-71.
(2013). IL-25 simultaneously elicits distinct populations of innate lymphoid cells and multipotent progenitor type 2 (MPPtype2) cells. JOURNAL OF EXPERIMENTAL MEDICINE. 210(9), 1823-1837.
(2013). T Cell Factor 1 Is Required for Group 2 Innate Lymphoid Cell Generation. IMMUNITY. 38(4), 694-704.
(2013). T cell development requires constraint of the myeloid regulator C/EBP-alpha by the Notch target and transcriptional repressor Hes1. NATURE IMMUNOLOGY. 14(12), 1277-+.
(2012). Expression of Functional P-Selectin Glycoprotein Ligand 1 on Hematopoietic Progenitors Is Developmentally Regulated. JOURNAL OF IMMUNOLOGY. 188(9), 4385-4393.
(2012). HEMATOPOIESIS & STEM CELLS Decoding HSC heterogeneity. BLOOD. 119(21), 4819-4820.
(2012). Losing TREC with Age. IMMUNITY. 36(2), 163-165.
(2012). Rebuilding the Thymus. SCIENCE. 336(6077), 40-41.
(2011). A critical role for TCF-1 in T-lineage specification and differentiation. NATURE. 476(7358), 63-+.
(2011). Cutting Edge: Natural Helper Cells Derive from Lymphoid Progenitors. JOURNAL OF IMMUNOLOGY. 187(11), 5505-5509.
(2011). Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation. BLOOD. 118(7), 1962-1970.
(2011). Erythroid/Myeloid Progenitors and Hematopoietic Stem Cells Originate from Distinct Populations of Endothelial Cells. Cell Stem Cell. 9(6), 541-552.

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Academic Articles110