- Senior Investigator, Laboratory of Metabolism
Dr. Gonzalez received his Ph.D. from the University of Wisconsin in Madison and was a staff fellow at the National Institute of Child Health and Human Development prior to joining the NCI. He received the Rawls Palmer Progress in Medicine Award from the American Society for Clinical Pharmacology, the John J. Abel Award and the Bernard B. Brodie Award in Drug Metabolism from the American Society of Pharmacology and Experimental Therapeutics, the George Scott Award from the Toxicology Forum, the North American Achievement Award from the International Society for the Study of Xenobiotics, the Elizabeth and James Miller Award in Experimental Oncology and an honorary D.Sc. from Mahidol University, Thailand. Dr. Gonzalez is an honorary member of the Society of Toxicology and an honorary fellow of the Royal College of Physicians of Thailand. He is a 12-time recipient of the Federal Technology Transfer Award and has two NIH Merit Awards. He is the co-inventor of 16 patents. His studies are largely focused on the role of cytochromes P450 and xenobiotic receptors in drug metabolism and chemical carcinogenesis.
Articles3
- (2020). Dexamethasone-Induced Liver Enlargement Is Related to PXR/YAP Activation and Lipid Accumulation but Not Hepatocyte Proliferation. DRUG METABOLISM AND DISPOSITION.
- (2020). Incident Chronic Kidney Disease Risk among Hispanics/Latinos in the United States: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL). JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 31(6), 1315-1324.
- (2015). Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity. JOURNAL OF HEPATOLOGY. 62(6), 1398-1404.
Academic Articles1138
- (2020). Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice. TOXICOLOGY LETTERS. 333, 290-302.
- (2020). Synergistic regulation of hepatic Fsp27b expression by HNF4 alpha and CREBH. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 530(2), 432-439.
- (2020). Brain Testosterone-CYP1B1 (Cytochrome P450 1B1) Generated Metabolite 6 beta-Hydroxytestosterone Promotes Neurogenic Hypertension and Inflammation. HYPERTENSION. 76(3), 1006-1018.
- (2020). Dexamethasone-Induced Liver Enlargement Is Related to PXR/YAP Activation and Lipid Accumulation but Not Hepatocyte Proliferation. DRUG METABOLISM AND DISPOSITION.
- (2020). Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice. Liver Cancer. 9(5), 529-548.