- Senior Investigator, Clinical Research Branch / Environmental Autoimmunity Group
Dr. Frederick Miller is Chief of the Environmental Autoimmunity Group in the National Institute of Environmental Health Sciences at the NIH, Bethesda, MD. He oversees investigators in his group as well as others in national and international consortia that evaluate and conduct a wide range of basic and clinical studies on adult and juvenile autoimmune diseases. He obtained his M.D. and Ph.D. from Case Western Reserve University, went on to medical residencies at Emory and Stanford, and then did rheumatology and immunology training at the NIH. His work in the field of autoimmune diseases spans three decades and involves many aspects of the environmental risk factors, epidemiology, immunology, genetics, pathogenesis, evaluation and treatment of immune-mediated diseases. He has focused much of his work on autoimmune muscle diseases. He is leading a number of studies to identify environmental and genetic risk factors for autoimmunity and systemic autoimmune diseases.
- (2016). Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups. ANNALS OF THE RHEUMATIC DISEASES. 75(8), 1558-1566.
- (2012). Age-Related Somatic Structural Changes in the Nuclear Genome of Human Blood Cells. AMERICAN JOURNAL OF HUMAN GENETICS. 90(2), 217-228.
- (2020). Endothelial Activation Markers as Disease Activity and Damage Measures in Juvenile Dermatomyositis. JOURNAL OF RHEUMATOLOGY. 47(7), 1011-1018.
- (2020). Expression of interferon-regulated genes in juvenile dermatomyositis versus Mendelian autoinflammatory interferonopathies. ARTHRITIS RESEARCH & THERAPY. 22(1),