Aguilera, Greti, M.D. individual record
Senior Investigator
Positions:
  • Senior Investigator, Section on Endocrine Physiology
overview

Dr. Greti Aguilera received an M.D. degree from the University of Chile in 1968. She trained in Clinical Endocrinology, Department of Medicine, University of Chile, and in basic research on steroid biochemistry in the Department of Physiology and Biophysics.  In 1975 she joined Dr. Kevin Catt's laboratory at NICHD as an International Fogarty Fellow, in 1977 she was appointed as Visiting Scientist, and then as a Senior Researcher in 1984. Since 1989, she has served as Chief of the Section of Endocrine Physiology within the Program on Developmental Endocrinology and Genetics in NICHD.  Research contributions include identification of factors responsible for regulation of adrenal glomerulosa responsiveness to angiotensin II; characterization of the relative role of corticotropin releasing hormone and vasopressin on the HPA axis adaptation during stress; characterization of the properties, signaling-transduction, and regulation of the receptors for these peptide hormones, and the identification of novel mechanisms for the transcriptional regulation of CRH. Current work in Dr. Aguilera's laboratory focuses on the molecular mechanisms of positive and negative regulation of CRH transcription responsible for the rapid but transient responses to stress, the consequences of early life experiences and circadian and ultradian rhythms of glucocorticoid secretion on gene transcription, and the mechanisms determining pulsatile glucocorticoid secretion by the adrenal.

selected publications
Academic Articles214