Scholars

Senior Investigator

Positions:

Senior Investigator, Signal Transduction Laboratory / Calcium Regulation Group

overview

Dr. Putney received his Ph.D. from the Medical College of Virginia, and held academic posts at Wayne State University and the Medical College of Virginia where he achieved the rank of Professor of Pharmacology. His current position is Chief, Calcium Regulation Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences. Formerly he served as Chief of the Laboratory of Cellular and Molecular Pharmacology. He also holds positions as Adjunct Professor of Pharmacology at the University of North Carolina, and Affiliate Professor of Pharmacology and Toxicology, Virginia Commonwealth University.

selected publications

Academic Articles255

(2019). A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction. Nature Communications. 10,
(2019). Store-operated Ca2+ entry and Ca2+ responses to hypothalamic releasing hormones in anterior pituitary cells from Orai1-/- and heptaTRPC knockout mice. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1866(7), 1124-1136.
(2018). A personal journey. CELL CALCIUM. 72, 127-131.
(2018). Orai1 Plays a Crucial Role in Central Sensitization by Modulating Neuronal Excitability. JOURNAL OF NEUROSCIENCE. 38(4), 887-900.
(2017). Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 114(52), 13786-13791.
(2017). ORAI Calcium Channels. PHYSIOLOGY. 32(4), 332-342.
(2017). SOCE: Fundamental Mechanistic Concepts Introduction. Advances in Experimental Medicine and Biology. 993, 3-13.
(2017). The functions of store-operated calcium channels. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1864(6), 900-906.
(2016). Low-Voltage-Activated Ca(V)3.1 Calcium Channels Shape T Helper Cell Cytokine Profiles. IMMUNITY. 44(4), 782-794.
(2016). Male infertility in mice lacking the store-operated Ca2+ channel Orai1. CELL CALCIUM. 59(4), 189-197.
(2016). TRPC3 amplifies B-cell receptor-induced ERK signalling via protein kinase D-dependent Rap1 activation. BIOCHEMICAL JOURNAL. 473, 201-210.
(2015). Essential role of Orai1 store-operated calcium channels in lactation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 112(18), 5827-5832.
(2015). Multiple types of calcium channels arising from alternative translation initiation of the Orai1 message. Science Signaling. 8(387),
(2015). Retrograde regulation of STIM1-Orai1 interaction and store-operated Ca2+ entry by calsequestrin. Scientific Reports. 5,
(2015). Role of the store-operated calcium entry protein, STIM1, in neutrophil chemotaxis and infiltration into a murine model of psoriasis-inflamed skin. FASEB JOURNAL. 29(7), 3003-3013.
(2014). Calcium signaling in lacrimal glands. CELL CALCIUM. 55(6), 290-296.
(2014). Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent. ONCOGENE. 33(18), 2307-2316.
(2014). Role of Orai1 and store-operated calcium entry in mouse lacrimal gland signalling and function. JOURNAL OF PHYSIOLOGY-LONDON. 592(5), 927-939.
(2013). Alternative Forms of the Store-Operated Calcium Entry Mediators, STIM1 and Orai1. Current Topics in Membranes. 71, 109-123.
(2013). Calcium Signaling: Septins Organize the SOC Channel. CURRENT BIOLOGY. 23(16), R684-R685.
(2013). Role of STIM1-and Orai1-mediated Ca2+ entry in Ca2+-induced epidermal keratinocyte differentiation. JOURNAL OF CELL SCIENCE. 126(2), 605-612.
(2012). Alternative translation initiation gives rise to two isoforms of Orai1 with distinct plasma membrane mobilities. JOURNAL OF CELL SCIENCE. 125(18), 4354-4361.
(2012). Calcium Signaling: Deciphering the Calcium-NFAT Pathway. CURRENT BIOLOGY. 22(3), R87-R89.
(2012). Deletion of Orai1 alters expression of multiple genes during osteoclast and osteoblast maturation. CELL CALCIUM. 52(6), 488-500.
(2012). Orai1-mediated calcium entry plays a critical role in osteoclast differentiation and function by regulating activation of the transcription factor NFATc1. FASEB JOURNAL. 26(4), 1484-1492.
(2012). Phosphoregulation of STIM1 Leads to Exclusion of the Endoplasmic Reticulum from the Mitotic Spindle. CURRENT BIOLOGY. 22(16), 1487-1493.
(2012). Regulation of store-operated calcium entry during cell division. BIOCHEMICAL SOCIETY TRANSACTIONS. 40, 119-123.
(2011). Calcium Oscillations. Cold Spring Harbor Perspectives in Biology. 3(3),
(2011). Calcium signaling in osteoclasts. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1813(5), 979-983.
(2011). The Physiological Function of Store-operated Calcium Entry. NEUROCHEMICAL RESEARCH. 36(7), 1157-1165.
(2010). Activation and regulation of store-operated calcium entry. 14(10), 2337-2349.
(2010). Ca2+ influx and protein scaffolding via TRPC3 sustain PKC beta and ERK activation in B cells. JOURNAL OF CELL SCIENCE. 123(6), 927-938.
(2010). Pharmacology of Store-operated Calcium Channels. 10(4), 209-218.
(2009). Capacitative calcium entry: from concept to molecules. IMMUNOLOGICAL REVIEWS. 231, 10-22.
(2009). Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 457(4), 757-769.
(2009). Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis. NATURE CELL BIOLOGY. 11(12), 1465-U190.
(2009). Regulation of calcium entry in exocrine gland cells and other epithelial cells. JOURNAL OF MEDICAL INVESTIGATION. 56, 362-367.
(2009). SOC: now also store-operated cyclase. NATURE CELL BIOLOGY. 11(4), 381-382.
(2009). STIM1 Is a Calcium Sensor Specialized for Digital Signaling. CURRENT BIOLOGY. 19(20), 1724-1729.
(2009). Store operated calcium entry in NIH-3T3 cells. JOURNAL OF MEDICAL INVESTIGATION. 56, 381-382.
(2009). TRPC channels function independently of STIM1 and Orai1. JOURNAL OF PHYSIOLOGY-LONDON. 587(10), 2275-2298.
(2008). Ca2+-store-dependent and -independent reversal of Stim1 localization and function. JOURNAL OF CELL SCIENCE. 121(6), 762-772.
(2008). Calcium influx mechanisms underlying calcium oscillations in rat hepatocytes. HEPATOLOGY. 48(4), 1273-1281.
(2008). Complex actions of 2-aminoethyldiphenyl borate on store-operated calcium entry. JOURNAL OF BIOLOGICAL CHEMISTRY. 283(28), 19265-19273.
(2008). Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5-bisphosphate. CELL CALCIUM. 43(5), 506-514.
(2008). Cytoplasmic calcium oscillations and store-operated calcium influx. JOURNAL OF PHYSIOLOGY-LONDON. 586(13), 3055-3059.
(2008). Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels. NATURE IMMUNOLOGY. 9(1), 89-96.
(2008). Methods for studying store-operated calcium entry. METHODS. 46(3), 204-212.
(2008). STIM1 is a MT-plus-end-tracking protein involved in remodeling of the ER. CURRENT BIOLOGY. 18(3), 177-182.
(2007). Ca2+ mobilization through dorsal root ganglion Ca2+-sensing receptor stably expressed in HEK293 cells. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 292(5), C1895-C1905.
(2007). Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels. JOURNAL OF BIOLOGICAL CHEMISTRY. 282(24), 17548-17556.
(2007). Inositol lipids and TRPC channel activation. 74, 37-45.
(2007). New molecular players in capacitative Ca2+ entry. JOURNAL OF CELL SCIENCE. 120(12), 1959-1965.
(2007). Recent breakthroughs in the molecular mechanism of capacitative calcium entry (with thoughts on how we got here). CELL CALCIUM. 42(2), 103-110.
(2007). Role of the microtubule cytoskeleton in the function of the store-operated Ca2+ channel activator STIM1. JOURNAL OF CELL SCIENCE. 120(21), 3762-3771.
(2007). Role of the store-operated calcium entry proteins Stim1 and Orai1 in muscarinic cholinergic receptor-stimulated calcium oscillations in human embryonic kidney cells. JOURNAL OF PHYSIOLOGY-LONDON. 579(3), 679-689.
(2006). Calcium signaling: Double duty for calcium at the mitochondrial uniporter. CURRENT BIOLOGY. 16(18), R812-R815.
(2006). Dissociation of regulated trafficking of TRPC3 channels to the plasma membrane from their activation by phospholipase C. JOURNAL OF BIOLOGICAL CHEMISTRY. 281(17), 11712-11720.
(2006). Emerging perspectives in store-operated Ca2+ entry: Roles of Orai, Stim and TRP. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1763(11), 1147-1160.
(2006). Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. JOURNAL OF BIOLOGICAL CHEMISTRY. 281(34), 24979-24990.
(2006). Native TRPC7 channel activation by an inositol trisphosphate receptor-dependent mechanism. JOURNAL OF BIOLOGICAL CHEMISTRY. 281(35), 25250-25258.
(2006). Protection of TRPC7 cation channels from calcium inhibition by closely associated SERCA pumps. FASEB JOURNAL. 20(1), 503-+.
(2005). Ca2+-calmodulin-dependent facilitation and Ca2+ inactivation of Ca2+ release-activated Ca2+ channel. JOURNAL OF BIOLOGICAL CHEMISTRY. 280(10), 8776-8783.
(2005). Capacitative calcium entry supports calcium oscillations in human embryonic kidney cells. JOURNAL OF PHYSIOLOGY-LONDON. 562(3), 697-706.
(2005). Capacitative calcium entry: sensing the calcium stores. JOURNAL OF CELL BIOLOGY. 169(3), 381-382.
(2005). Mechanism of inhibition of TRPC cation channels by 2-aminoethoxydiphenylborane. MOLECULAR PHARMACOLOGY. 68(3), 758-762.
(2005). Negative regulation of TRPC3 channels by protein kinase C-mediated phosphorylation of serine 712. MOLECULAR PHARMACOLOGY. 67(2), 558-563.
(2005). Physiological mechanisms of TRPC activation. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 451(1), 29-34.
(2005). Store-operated calcium channels. PHYSIOLOGICAL REVIEWS. 85(2), 757-810.
(2005). The role of canonical transient receptor potential 7 in B-cell receptor-activated channels. JOURNAL OF BIOLOGICAL CHEMISTRY. 280(42), 35346-35351.
(2004). Canonical transient receptor potential TRPC7 can function as both a receptor- and store-operated channel in HEK-293 cells. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 287(6), C1709-C1716.
(2004). Mechanisms of phospholipase C-regulated calcium entry. CURRENT MOLECULAR MEDICINE. 4(3), 291-301.
(2004). Obligatory role of Src kinase in the signaling mechanism for TRPC3 cation channels. JOURNAL OF BIOLOGICAL CHEMISTRY. 279(39), 40521-40528.
(2004). The enigmatic TRPCs: multifunctional cation channels. TRENDS IN CELL BIOLOGY. 14(6), 282-286.
(2004). The mammalian TRPC cation channels. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1742(1-3), 21-36.
(2003). 2-aminoethoxydiphenyl borane activates a novel calcium-permeable cation channel. MOLECULAR PHARMACOLOGY. 63(6), 1304-1311.
(2003). A calmodulin/inositol 1,4,5-trisphosphate (IP3) receptor-binding region targets TRPC3 to the plasma membrane in a calmodulin/IP3 receptor-independent process. JOURNAL OF BIOLOGICAL CHEMISTRY. 278(28), 25758-25765.
(2003). Capacitative calcium entry in the nervous system. CELL CALCIUM. 34(4-5), 339-344.
(2003). Expression level of the canonical transient receptor potential 3 (TRPC3) channel determines its mechanism of activation. JOURNAL OF BIOLOGICAL CHEMISTRY. 278(24), 21649-21654.
(2003). Signaling mechanism for receptor-activated canonical transient receptor potential 3 (TRPC3) channels. JOURNAL OF BIOLOGICAL CHEMISTRY. 278(18), 16244-16252.
(2003). The TRPC3/6/7 subfamily of cation channels. CELL CALCIUM. 33(5-6), 451-461.
(2002). An inositol 1,4,5-trisphosphate receptor-dependent cation entry pathway in DT40 B lymphocytes. EMBO JOURNAL. 21(17), 4531-4538.
(2002). Comparison of human TRPC3 channels in receptor-activated and store-operated modes - Differential sensitivity to channel blockers suggests fundamental differences in channel composition. JOURNAL OF BIOLOGICAL CHEMISTRY. 277(24), 21617-21623.
(2002). PLC-gamma: an old player has a new role. NATURE CELL BIOLOGY. 4(12), E280-E281.
(2001). Cell biology - Channelling calcium. NATURE. 410(6829), 648-649.
(2001). Human Trp3 forms both inositol trisphosphate receptor-dependent and receptor-independent store-operated cation channels in DT40 avian B lymphocytes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 98(20), 11777-11782.
(2001). Mechanisms of capacitative calcium entry. JOURNAL OF CELL SCIENCE. 114(12), 2223-2229.
(2001). Mutual antagonism of calcium entry by capacitative and arachidonic acid-mediated calcium entry pathways. JOURNAL OF BIOLOGICAL CHEMISTRY. 276(23), 20186-20189.
(2001). Role of the phospholipase C-inositol 1,4,5-trisphosphate pathway in calcium release-activated calcium current and capacitative calcium entry. JOURNAL OF BIOLOGICAL CHEMISTRY. 276(19), 15945-15952.
(2001). Signaling pathways underlying muscarinic receptor-induced [Ca2+](i) oscillations in HEK293 cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 276(8), 5613-5621.
(2001). Stable activation of single Ca2+ release-activated Ca2+ channels in divalent cation-free solutions. JOURNAL OF BIOLOGICAL CHEMISTRY. 276(2), 1063-1070.
(2000). A selective requirement for elevated calcium in DNA degradation, but not early events in anti-Fas-induced apoptosis. JOURNAL OF BIOLOGICAL CHEMISTRY. 275(39), 30586-30596.
(2000). Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3. BIOCHEMICAL JOURNAL. 351, 735-746.
(2000). Effects of elevated cytoplasmic calcium and protein kinase C on endoplasmic reticulum structure and function in HEK293 cells. CELL CALCIUM. 27(3), 175-185.
(2000). Presenilins, Alzheimer's disease, and capacitative calcium entry. NEURON. 27(3), 411-412.
(2000). Signaling pathways between the plasma membrane and endoplasmic reticulum calcium stores. CELLULAR AND MOLECULAR LIFE SCIENCES. 57(8-9), 1272-1286.
(1999). "Kissin' cousins": Intimate plasma membrane-ER interactions underlie capacitative calcium entry. CELL. 99(1), 5-8.
(1999). Adenophostin A induces spatially restricted calcium signaling in Xenopus laevis oocytes. JOURNAL OF BIOLOGICAL CHEMISTRY. 274(29), 20643-20649.
(1999). Capacitative calcium entry channels. BIOESSAYS. 21(1), 38-46.
(1999). Role of the inositol 1,4,5-trisphosphate receptor in Ca2+ feedback inhibition of calcium release-activated calcium current (I-crac). JOURNAL OF BIOLOGICAL CHEMISTRY. 274(46), 32881-32888.

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Academic Articles255