Putney, James W., Ph.D.
individual record
Senior Investigator
Positions:
- Senior Investigator, Signal Transduction Laboratory / Calcium Regulation Group
overview
Dr. Putney received his Ph.D. from the Medical College of Virginia, and held academic posts at Wayne State University and the Medical College of Virginia where he achieved the rank of Professor of Pharmacology. His current position is Chief, Calcium Regulation Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences. Formerly he served as Chief of the Laboratory of Cellular and Molecular Pharmacology. He also holds positions as Adjunct Professor of Pharmacology at the University of North Carolina, and Affiliate Professor of Pharmacology and Toxicology, Virginia Commonwealth University.
selected publications
Academic Articles255
- (2019). A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction. Nature Communications. 10,
- (2019). Store-operated Ca2+ entry and Ca2+ responses to hypothalamic releasing hormones in anterior pituitary cells from Orai1-/- and heptaTRPC knockout mice. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1866(7), 1124-1136.
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- (2018). Orai1 Plays a Crucial Role in Central Sensitization by Modulating Neuronal Excitability. JOURNAL OF NEUROSCIENCE. 38(4), 887-900.
- (2017). Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 114(52), 13786-13791.
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- (2017). SOCE: Fundamental Mechanistic Concepts Introduction. Advances in Experimental Medicine and Biology. 993, 3-13.
- (2017). The functions of store-operated calcium channels. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 1864(6), 900-906.
- (2016). Low-Voltage-Activated Ca(V)3.1 Calcium Channels Shape T Helper Cell Cytokine Profiles. IMMUNITY. 44(4), 782-794.
- (2016). Male infertility in mice lacking the store-operated Ca2+ channel Orai1. CELL CALCIUM. 59(4), 189-197.
- (2016). TRPC3 amplifies B-cell receptor-induced ERK signalling via protein kinase D-dependent Rap1 activation. BIOCHEMICAL JOURNAL. 473, 201-210.
- (2015). Essential role of Orai1 store-operated calcium channels in lactation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 112(18), 5827-5832.
- (2015). Multiple types of calcium channels arising from alternative translation initiation of the Orai1 message. Science Signaling. 8(387),
- (2015). Retrograde regulation of STIM1-Orai1 interaction and store-operated Ca2+ entry by calsequestrin. Scientific Reports. 5,
- (2015). Role of the store-operated calcium entry protein, STIM1, in neutrophil chemotaxis and infiltration into a murine model of psoriasis-inflamed skin. FASEB JOURNAL. 29(7), 3003-3013.
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- (2014). Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent. ONCOGENE. 33(18), 2307-2316.
- (2014). Role of Orai1 and store-operated calcium entry in mouse lacrimal gland signalling and function. JOURNAL OF PHYSIOLOGY-LONDON. 592(5), 927-939.
- (2013). Alternative Forms of the Store-Operated Calcium Entry Mediators, STIM1 and Orai1. Current Topics in Membranes. 71, 109-123.
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- (2013). Role of STIM1-and Orai1-mediated Ca2+ entry in Ca2+-induced epidermal keratinocyte differentiation. JOURNAL OF CELL SCIENCE. 126(2), 605-612.
- (2012). Alternative translation initiation gives rise to two isoforms of Orai1 with distinct plasma membrane mobilities. JOURNAL OF CELL SCIENCE. 125(18), 4354-4361.
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- (2012). Deletion of Orai1 alters expression of multiple genes during osteoclast and osteoblast maturation. CELL CALCIUM. 52(6), 488-500.
- (2012). Orai1-mediated calcium entry plays a critical role in osteoclast differentiation and function by regulating activation of the transcription factor NFATc1. FASEB JOURNAL. 26(4), 1484-1492.