Diamond, Jeffrey S., Ph.D.
individual record
Senior Investigator
Positions:
- Senior Investigator, Synaptic Physiology Section
overview
Dr. Diamond received his B.S. from Duke University in 1989 and his Ph.D. from the University of California, San Francisco in 1994, where he studied excitatory synaptic transmission in the retina with David Copenhagen. During a postdoctoral fellowship with Craig Jahr at the Vollum Institute, he investigated the effects of glutamate transporters on excitatory synaptic transmission in the hippocampus. Dr. Diamond joined NINDS as an investigator in 1999, was awarded the Presidential Early Career Award in Science and Engineering in 2000 and was promoted to senior investigator in 2007. His laboratory explores the dynamics and modulation of transmitter release, diffusion and receptor activation at excitatory and inhibitory synapses in the mammalian CNS.
selected publications
Academic Articles59
- (2019). Ganglion Cells in Primate Retina Use Fuzzy Logic to Encode Complex Visual Receptive Fields. NEURON. 103(4), 549-551.
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- (2018). Functional Compartmentalization within Starburst Amacrine Cell Dendrites in the Retina. Cell Reports. 22(11), 2898-2908.
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- (2018). Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts. JOURNAL OF VIROLOGY. 92(18),
- (2018). Synaptic Transfer between Rod and Cone Pathways Mediated by All Amacrine Cells in the Mouse Retina. CURRENT BIOLOGY. 28(17), 2739-+.
- (2017). Inhibitory Interneurons in the Retina: Types, Circuitry, and Function. Annual Review of Vision Science. 3, 1-24.
- (2016). Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS. ACTA NEUROPATHOLOGICA. 132(6), 827-840.
- (2016). High-Resolution Quantitative Immunogold Analysis of Membrane Receptors at Retinal Ribbon Synapses. Jove-Journal of Visualized Experiments. (108),
- (2016). NMDA Receptors Multiplicatively Scale Visual Signals and Enhance Directional Motion Discrimination in Retinal Ganglion Cells. NEURON. 89(6), 1277-1290.
- (2016). Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina. JOURNAL OF NEUROSCIENCE. 36(9), 2827-2842.
- (2016). Retinal Circuitry Balances Contrast Tuning of Excitation and Inhibition to Enable Reliable Computation of Direction Selectivity. JOURNAL OF NEUROSCIENCE. 36(21), 5861-5876.
- (2016). Species-specific wiring for direction selectivity in the mammalian retina. NATURE. 535(7610), 105-+.
- (2015). Complex inhibitory microcircuitry regulates retinal signaling near visual threshold. JOURNAL OF NEUROPHYSIOLOGY. 114(1), 341-353.
- (2015). Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line. Scientific Reports. 5,
- (2014). CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses. NATURE NEUROSCIENCE. 17(1), 56-64.
- (2014). Passive Diffusion as a Mechanism Underlying Ribbon Synapse Vesicle Release and Resupply. JOURNAL OF NEUROSCIENCE. 34(27), 8948-8962.
- (2014). Specialized Postsynaptic Morphology Enhances Neurotransmitter Dilution and High-Frequency Signaling at an Auditory Synapse. JOURNAL OF NEUROSCIENCE. 34(24), 8358-8372.
- (2013). Amyloid-beta(1-42) Slows Clearance of Synaptically Released Glutamate by Mislocalizing Astrocytic GLT-1. JOURNAL OF NEUROSCIENCE. 33(12), 5312-5318.
- (2013). Deriving the Time Course of Glutamate Clearance with a Deconvolution Analysis of Astrocytic Transporter Currents. Jove-Journal of Visualized Experiments. (78),
- (2012). Amacrine cells: Seeing the forest and the trees INTRODUCTION. VISUAL NEUROSCIENCE. 29(1), 1-2.
- (2012). The Number and Organization of Ca2+ Channels in the Active Zone Shapes Neurotransmitter Release from Schaffer Collateral Synapses. JOURNAL OF NEUROSCIENCE. 32(50), 18157-18176.
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- (2011). Genetic targeting and physiological features of VGLUT3+amacrine cells. VISUAL NEUROSCIENCE. 28(5), 381-392.