Diamond, Jeffrey S., Ph.D.
individual record
Senior Investigator
Positions:
- Senior Investigator, Synaptic Physiology Section
overview
Dr. Diamond received his B.S. from Duke University in 1989 and his Ph.D. from the University of California, San Francisco in 1994, where he studied excitatory synaptic transmission in the retina with David Copenhagen. During a postdoctoral fellowship with Craig Jahr at the Vollum Institute, he investigated the effects of glutamate transporters on excitatory synaptic transmission in the hippocampus. Dr. Diamond joined NINDS as an investigator in 1999, was awarded the Presidential Early Career Award in Science and Engineering in 2000 and was promoted to senior investigator in 2007. His laboratory explores the dynamics and modulation of transmitter release, diffusion and receptor activation at excitatory and inhibitory synapses in the mammalian CNS.
selected publications
Academic Articles59
- (2019). Ganglion Cells in Primate Retina Use Fuzzy Logic to Encode Complex Visual Receptive Fields. NEURON. 103(4), 549-551.
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- (2018). Functional Compartmentalization within Starburst Amacrine Cell Dendrites in the Retina. Cell Reports. 22(11), 2898-2908.
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- (2018). Localized Induction of Wild-Type and Mutant Alpha-Synuclein Aggregation Reveals Propagation along Neuroanatomical Tracts. JOURNAL OF VIROLOGY. 92(18),
- (2018). Synaptic Transfer between Rod and Cone Pathways Mediated by All Amacrine Cells in the Mouse Retina. CURRENT BIOLOGY. 28(17), 2739-+.
- (2017). Inhibitory Interneurons in the Retina: Types, Circuitry, and Function. Annual Review of Vision Science. 3, 1-24.
- (2016). Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS. ACTA NEUROPATHOLOGICA. 132(6), 827-840.
- (2016). High-Resolution Quantitative Immunogold Analysis of Membrane Receptors at Retinal Ribbon Synapses. Jove-Journal of Visualized Experiments. (108),
- (2016). NMDA Receptors Multiplicatively Scale Visual Signals and Enhance Directional Motion Discrimination in Retinal Ganglion Cells. NEURON. 89(6), 1277-1290.
- (2016). Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina. JOURNAL OF NEUROSCIENCE. 36(9), 2827-2842.
- (2016). Retinal Circuitry Balances Contrast Tuning of Excitation and Inhibition to Enable Reliable Computation of Direction Selectivity. JOURNAL OF NEUROSCIENCE. 36(21), 5861-5876.
- (2016). Species-specific wiring for direction selectivity in the mammalian retina. NATURE. 535(7610), 105-+.
- (2015). Complex inhibitory microcircuitry regulates retinal signaling near visual threshold. JOURNAL OF NEUROPHYSIOLOGY. 114(1), 341-353.
- (2015). Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line. Scientific Reports. 5,
- (2014). CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses. NATURE NEUROSCIENCE. 17(1), 56-64.
- (2014). Passive Diffusion as a Mechanism Underlying Ribbon Synapse Vesicle Release and Resupply. JOURNAL OF NEUROSCIENCE. 34(27), 8948-8962.
- (2014). Specialized Postsynaptic Morphology Enhances Neurotransmitter Dilution and High-Frequency Signaling at an Auditory Synapse. JOURNAL OF NEUROSCIENCE. 34(24), 8358-8372.
- (2013). Amyloid-beta(1-42) Slows Clearance of Synaptically Released Glutamate by Mislocalizing Astrocytic GLT-1. JOURNAL OF NEUROSCIENCE. 33(12), 5312-5318.
- (2013). Deriving the Time Course of Glutamate Clearance with a Deconvolution Analysis of Astrocytic Transporter Currents. Jove-Journal of Visualized Experiments. (78),
- (2012). Amacrine cells: Seeing the forest and the trees INTRODUCTION. VISUAL NEUROSCIENCE. 29(1), 1-2.
- (2012). The Number and Organization of Ca2+ Channels in the Active Zone Shapes Neurotransmitter Release from Schaffer Collateral Synapses. JOURNAL OF NEUROSCIENCE. 32(50), 18157-18176.
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- (2011). Genetic targeting and physiological features of VGLUT3+amacrine cells. VISUAL NEUROSCIENCE. 28(5), 381-392.
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- (2011). Illuminating synapses and circuitry in the retina. CURRENT OPINION IN NEUROBIOLOGY. 21(2), 238-244.
- (2011). Ribbon synapses compute temporal contrast and encode luminance in retinal rod bipolar cells. NATURE NEUROSCIENCE. 14(12), 1555-U84.
- (2011). The Relative Roles of Diffusion and Uptake in Clearing Synaptically Released Glutamate Change during Early Postnatal Development. JOURNAL OF NEUROSCIENCE. 31(12), 4743-4754.
- (2010). Mechanisms Underlying Lateral GABAergic Feedback onto Rod Bipolar Cells in Rat Retina. JOURNAL OF NEUROSCIENCE. 30(6), 2330-2339.
- (2010). Probing potassium channel function in vivo by intracellular delivery of antibodies in a rat model of retinal neurodegeneration. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107(28), 12710-12715.
- (2010). Retinal Parallel Processors: More than 100 Independent Microcircuits Operate within a Single Interneuron. NEURON. 65(6), 873-885.
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- (2009). BK channels modulate pre- and postsynaptic signaling at reciprocal synapses in retina. NATURE NEUROSCIENCE. 12(5), 585-592.
- (2009). Coagonist Release Modulates NMDA Receptor Subtype Contributions at Synaptic Inputs to Retinal Ganglion Cells. JOURNAL OF NEUROSCIENCE. 29(5), 1469-1479.
- (2009). Neuronal Transporters Regulate Glutamate Clearance, NMDA Receptor Activation, and Synaptic Plasticity in the Hippocampus. JOURNAL OF NEUROSCIENCE. 29(46), 14581-14595.
- (2009). Subunit- and Pathway-Specific Localization of NMDA Receptors and Scaffolding Proteins at Ganglion Cell Synapses in Rat Retina. JOURNAL OF NEUROSCIENCE. 29(13), 4274-4286.
- (2008). Diverse mechanisms underlie glycinergic feedback transmission onto rod biopolar cells in rat retina. JOURNAL OF NEUROSCIENCE. 28(31), 7919-7928.
- (2007). A light switch controlling Ca2+-permeable AMPA receptors in the retina. JOURNAL OF PHYSIOLOGY-LONDON. 582(1), 3-3.
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- (2006). Distinct perisynaptic and synaptic localization of NMDA and AMPA receptors on ganglion cells in rat retina. JOURNAL OF COMPARATIVE NEUROLOGY. 498(6), 810-820.
- (2006). Fast neurotransmitter release triggered by Ca influx through AMPA-type glutamate receptors. NATURE. 443(7112), 705-708.
- (2006). Vesicle depletion and synaptic depression at a mammalian ribbon synapse. JOURNAL OF NEUROPHYSIOLOGY. 95(5), 3191-3198.
- (2005). Deriving the glutamate clearance time course from transporter currents in CA1 hippocampal astrocytes: Transmitter uptake gets faster during development. JOURNAL OF NEUROSCIENCE. 25(11), 2906-2916.
- (2004). Coordinated multivesicular release at a mammalian ribbon synapse. NATURE NEUROSCIENCE. 7(8), 826-833.
- (2004). Invulnerability of retinal ganglion cells to NMDA excitotoxicity. MOLECULAR AND CELLULAR NEUROSCIENCE. 26(4), 544-557.
- (2003). Neuronal glutamate uptake contributes to GABA synthesis and inhibitory synaptic strength. JOURNAL OF NEUROSCIENCE. 23(6), 2040-2048.
- (2003). Sustained Ca2+ entry elicits transient postsynaptic currents at a retinal ribbon synapse. JOURNAL OF NEUROSCIENCE. 23(34), 10923-10933.
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