Tsang, John S., Ph.D., B.A.Sc., M.Math individual record
  • Investigator, Systems Genomics and Bioinformatics Unit

Dr. Tsang received his Ph.D. in biophysics from Harvard University and B.A.Sc. and M.Math. in computer engineering and computer science, respectively, from the University of Waterloo in Canada.

Dr. Tsang has been working on systems biology and genomics research in both academic and industrial settings for over a decade. After graduating from Waterloo in 2000, he helped pioneer high-throughput computational and experimental methods to annotate the then-freshly sequenced human genome using custom DNA microarrays at Rosetta Inpharmatics and then led a bioinformatics group at Caprion Proteomics. His doctoral research was conducted in Alexander van Oudenaarden’s laboratory at MIT, where he led research on the systems biology of microRNA-mediated regulation and stochastic gene expression in yeast. After earning his Ph.D. in 2008, he returned to Rosetta Inpharmatics Division of Merck Research Laboratories to work with Dr. Eric Schadt on integrative genomics and genetics of gene expression in human and mouse.

He is currently leading a research program to develop and apply computational and experimental approaches to study the immune system (aka, “systems immunology”). He was also jointly appointed as director of computational systems biology at the Trans-NIH Center for Human Immunology (CHI), where he recruited and now leads a group of computational biologists to integrate and analyze large-scale data sets to dissect the human immune system in health and disease.

selected publications
Academic Articles36