Scholars

Roche, Katherine W., Ph.D.

Senior Investigator

Positions:

Senior Investigator, Receptor Biology Section

Research Areas:

Cell Biology, Life Sciences & Biomedicine - Other Topics, Science & Technology - Other Topics, Biochemistry & Molecular Biology, Neurosciences & Neurology, Psychiatry, Pharmacology & Pharmacy

Co-author Network

Map of Science

ORCID

0000-0001-7282-6539

Research Areas:

Cell Biology, Life Sciences & Biomedicine - Other Topics, Science & Technology - Other Topics, Biochemistry & Molecular Biology, Neurosciences & Neurology, Psychiatry, Pharmacology & Pharmacy

overview

Dr. Roche received her B.S. from Duke University. In 1995 she received her Ph.D. from Johns Hopkins University, where she worked with Richard Huganir studying the regulation of glutamate receptors. She then did a postdoctoral fellowship with Robert Wenthold in the NIDCD, where she investigated the cell biology of glutamate receptor transport and localization. Dr. Roche joined NINDS as an Investigator in 2001. The main focus of her laboratory is the study of neurotransmitter receptor expression and targeting to the synapse.

selected publications

Articles1

(2020). A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y. NEURON. 106(5), 759-+.

Academic Articles90

(2020). An Epilepsy-Associated GRIN2A Rare Variant Disrupts CaMKII alpha Phosphorylation of GluN2A and NMDA Receptor Trafficking. Cell Reports. 32(9),
(2020). Neuroligins and Neurodevelopmental Disorders: X-Linked Genetics. Frontiers in Synaptic Neuroscience. 12,
(2020). Kalirin and Trio: RhoGEFs in Synaptic Transmission, Plasticity, and Complex Brain Disorders. TRENDS IN NEUROSCIENCES. 43(7), 505-518.
(2020). Regulation of NMDA glutamate receptor functions by the GluN2 subunits. JOURNAL OF NEUROCHEMISTRY. 154(2), 121-143.
(2020). A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y. NEURON. 106(5), 759-+.
(2020). Regulation of glutamate receptors by striatal-enriched tyrosine phosphatase 61 (STEP61). JOURNAL OF PHYSIOLOGY-LONDON.
(2020). DLG2 variants in patients with pubertal disorders. GENETICS IN MEDICINE. 22(8), 1329-1337.
(2019). Isoform-specific cleavage of neuroligin-3 reduces synapse strength. MOLECULAR PSYCHIATRY. 24(1), 145-160.
(2019). PSD-95 binding dynamically regulates NLGN1 trafficking and function. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 116(24), 12035-12044.
(2019). Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action. Cell Reports. 29(10), 2944-+.
(2019). The STEP61 interactome reveals subunit-specific AMPA receptor binding and synaptic regulation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 116(16), 8028-8037.
(2018). Metabotropic glutamate receptor trafficking. MOLECULAR AND CELLULAR NEUROSCIENCE. 91, 10-24.
(2018). The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms. Nature Communications. 9,
(2018). The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms (vol 8, 2069, 2018). Nature Communications. 9,
(2017). A Rare Variant Identified Within the GluN2B C-Terminus in a Patient with Autism Affects NMDA Receptor Surface Expression and Spine Density. JOURNAL OF NEUROSCIENCE. 37(15), 4093-4102.
(2017). MAGUKs: multifaceted synaptic organizers. CURRENT OPINION IN NEUROBIOLOGY. 43, 94-101.
(2017). Phosphorylation of the kainate receptor (KAR) auxiliary subunit Neto2 at serine 409 regulates synaptic targeting of the KAR subunit GluK1. JOURNAL OF BIOLOGICAL CHEMISTRY. 292(37), 15369-15377.
(2017). Posttranslational modifications of neuroligins regulate neuronal and glial signaling. CURRENT OPINION IN NEUROBIOLOGY. 45, 130-138.
(2017). Structural and molecular determinants regulating mGluR5 surface expression. NEUROPHARMACOLOGY. 115, 10-19.
(2016). GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons. Nature Communications. 7,
(2016). PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP61. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 113(32), E4736-E4744.
(2015). Autism-associated mutation inhibits protein kinase C-mediated neuroligin-4X enhancement of excitatory synapses. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 112(8), 2551-2556.
(2015). Dynamic Regulation of N-Methyl-d-aspartate (NMDA) and alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors by Posttranslational Modifications. JOURNAL OF BIOLOGICAL CHEMISTRY. 290(48), 28596-28603.
(2015). Neto auxiliary proteins control both the trafficking and biophysical properties of the kainate receptor GluK1. eLife. 4,
(2015). Neurolastin, a Dynamin Family GTPase, Regulates Excitatory Synapses and Spine Density. Cell Reports. 12(5), 743-751.
(2015). TARP gamma-8 glycosylation regulates the surface expression of AMPA receptors. BIOCHEMICAL JOURNAL. 465, 471-477.
(2015). The cellular and molecular landscape of neuroligins. TRENDS IN NEUROSCIENCES. 38(8), 496-505.
(2014). Autonomous CaMKII Mediates Both LTP and LTD Using a Mechanism for Differential Substrate Site Selection. Cell Reports. 6(3), 431-437.
(2014). CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses. NATURE NEUROSCIENCE. 17(1), 56-64.
(2014). Casein kinase 2 phosphorylates GluA1 and regulates its surface expression. EUROPEAN JOURNAL OF NEUROSCIENCE. 39(7), 1148-1158.
(2013). Activated CaMKII Couples GluN2B and Casein Kinase 2 to Control Synaptic NMDA Receptors. Cell Reports. 3(3), 607-614.
(2013). Cornichon Proteins Determine the Subunit Composition of Synaptic AMPA Receptors. NEURON. 77(6), 1083-1096.
(2013). Distance-Dependent Scaling of AMPARs Is Cell-Autonomous and GluA2 Dependent. JOURNAL OF NEUROSCIENCE. 33(33), 13312-13319.
(2013). Diversity in NMDA Receptor Composition: Many Regulators, Many Consequences. NEUROSCIENTIST. 19(1), 62-75.
(2013). Long-term potentiation: Peeling the onion. NEUROPHARMACOLOGY. 74, 18-22.
(2013). Regulation of Metabotropic Glutamate Receptor 7 (mGluR7) Internalization and Surface Expression by Ser/Thr Protein Phosphatase 1. JOURNAL OF BIOLOGICAL CHEMISTRY. 288(24), 17544-17551.
(2013). Support for the N-Methyl-D-Aspartate Receptor Hypofunction Hypothesis of Schizophrenia From Exome Sequencing in Multiplex Families. JAMA Psychiatry. 70(6), 582-590.
(2012). PKC Phosphorylation Regulates mGluR5 Trafficking by Enhancing Binding of Siah-1A. JOURNAL OF NEUROSCIENCE. 32(46), 16391-16401.
(2012). Posttranslational regulation of AMPA receptor trafficking and function. CURRENT OPINION IN NEUROBIOLOGY. 22(3), 470-479.
(2012). SAP102 Mediates Synaptic Clearance of NMDA Receptors. Cell Reports. 2(5), 1120-1128.
(2012). Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 109(47), 19426-19431.
(2011). Activity-Dependent Ubiquitination of the AMPA Receptor Subunit GluA2. JOURNAL OF NEUROSCIENCE. 31(8), 3077-3081.
(2011). Deletion of SNAP-23 Results in Pre-Implantation Embryonic Lethality in Mice. PLoS One. 6(3),
(2011). Differential Binding of Calmodulin to Group I Metabotropic Glutamate Receptors Regulates Receptor Trafficking and Signaling. JOURNAL OF NEUROSCIENCE. 31(16), 5921-5930.
(2011). Expression of the metabotropic glutamate receptor 5 (mGluR5) induces melanoma in transgenic mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 108(37), 15219-15224.
(2011). Functional dependence of neuroligin on a new non-PDZ intracellular domain. NATURE NEUROSCIENCE. 14(6), 718-U388.
(2011). NMDA Receptor-Dependent Regulation of Dendritic Spine Morphology by SAP102 Splice Variants. JOURNAL OF NEUROSCIENCE. 31(1), 89-96.
(2011). mGluR5 and NMDA Receptors Drive the Experience- and Activity-Dependent NMDA Receptor NR2B to NR2A Subunit Switch. NEURON. 70(2), 339-351.
(2010). A neuronal role for SNAP-23 in postsynaptic glutamate receptor trafficking. NATURE NEUROSCIENCE. 13(3), 338-U16.
(2010). Casein Kinase 2 Regulates the NR2 Subunit Composition of Synaptic NMDA Receptors. NEURON. 67(6), 984-996.
(2010). Differential Regulation of Kainate Receptor Trafficking by Phosphorylation of Distinct Sites on GluR6. JOURNAL OF BIOLOGICAL CHEMISTRY. 285(4), 2847-2856.
(2010). Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107(37), 16315-16319.
(2010). Novel Approach to Probe Subunit-specific Contributions to N-Methyl-D-aspartate (NMDA) Receptor Trafficking Reveals a Dominant Role for NR2B in Receptor Recycling. JOURNAL OF BIOLOGICAL CHEMISTRY. 285(27), 20975-20981.
(2010). Synaptic targeting of AMPA receptors is regulated by a CaMKII site in the first intracellular loop of GluA1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107(51), 22266-22271.
(2009). Dysbindin regulates hippocampal LTP by controlling NMDA receptor surface expression. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 106(50), 21395-21400.
(2009). Growth Factor-Dependent Trafficking of Cerebellar NMDA Receptors via Protein Kinase B/Akt Phosphorylation of NR2C. NEURON. 62(4), 471-478.
(2008). An essential role for PICK1 in NMDA receptor-dependent bidirectional synaptic plasticity. NEURON. 57(6), 872-882.
(2008). Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 105(34), 12575-12580.
(2008). Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7. NEURON. 58(5), 736-748.
(2008). Metabotropic glutamate receptors: Phosphorylation and receptor signaling. JOURNAL OF NEUROSCIENCE RESEARCH. 86(1), 1-10.
(2007). Constitutive endocytosis of the metabotropic glutamate receptor mGluR7 is clathrin-independent. NEUROPHARMACOLOGY. 52(1), 100-107.
(2007). Regulation of NMDA receptors by phosphorylation. NEUROPHARMACOLOGY. 53(3), 362-368.
(2007). mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082. NEUROPHARMACOLOGY. 52(1), 108-117.
(2006). Identification of an endoplasmic reticulum-retention motif in an intracellular loop of the kainate receptor subunit KA2. JOURNAL OF NEUROSCIENCE. 26(26), 7014-7021.
(2006). Regulation of NR1/NR2C N-methyl-D-aspartate (NMDA) receptors by phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY. 281(24), 16583-16590.
(2005). MGluR7 is a metaplastic switch controlling bidirectional plasticity of feedforward inhibition. NEURON. 46(1), 89-102.
(2005). Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on serine 839 regulates Ca2+ oscillations. JOURNAL OF BIOLOGICAL CHEMISTRY. 280(27), 25409-25415.
(2004). Kainate receptor trafficking: physiological roles and molecular mechanisms. PHARMACOLOGY & THERAPEUTICS. 104(3), 163-172.
(2004). Subunit-specific regulation of NMDA receptor endocytosis. JOURNAL OF NEUROSCIENCE. 24(28), 6383-6391.
(2004). The expanding role of PSD-95: a new link to addiction. TRENDS IN NEUROSCIENCES. 27(12), 699-700.
(2003). Differential binding of the AP-2 adaptor complex and PSD-95 to the C-terminus of the NMDA receptor subunit NR2B regulates surface expression. NEUROPHARMACOLOGY. 45(6), 729-737.
(2003). Trafficking and surface expression of the glutamate receptor subunit, KA2. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 310(1), 8-13.
(2002). Identification of rat EMAP, a delta-glutamate receptor binding protein. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 291(1), 85-90.
(2001). Molecular determinants of NMDA receptor internalization. NATURE NEUROSCIENCE. 4(8), 794-802.
(2000). PDZ domain suppression of an ER retention signal in NMDA receptor NR1 splice variants. NEURON. 28(3), 887-898.
(1999). Homer 1b regulates the trafficking of group I metabotropic glutamate receptors. JOURNAL OF BIOLOGICAL CHEMISTRY. 274(36), 25953-25957.
(1999). Postsynaptic density-93 interacts with the delta 2 glutamate receptor subunit at parallel fiber synapses. JOURNAL OF NEUROSCIENCE. 19(10), 3926-3934.
(1998). The organization and regulation of non-NMDA receptors in neurons. Progress in Brain Research. 116, 133-152.
(1997). AP-3: An adaptor-like protein complex with ubiquitous expression. EMBO JOURNAL. 16(5), 917-928.
(1997). Effect of magnesium sulfate on the development of cystic periventricular leukomalacia in preterm infants. AMERICAN JOURNAL OF PERINATOLOGY. 14(5), 303-307.
(1997). Functional domain mapping of the clathrin-associated adaptor medium chains mu 1 and mu 2. JOURNAL OF BIOLOGICAL CHEMISTRY. 272(43), 27160-27166.
(1997). Homer: A protein that selectively binds metabotropic glutamate receptors. NATURE. 386(6622), 284-288.
(1997). Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II. JOURNAL OF BIOLOGICAL CHEMISTRY. 272(51), 32528-32533.
(1996). Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit. NEURON. 16(6), 1179-1188.
(1996). Chronic steroid-responsive encephalitis without autoantibodies to glutamate receptor GluR3. NEUROLOGY. 46(1), 247-249.
(1996). Effect of immunization with a common recall antigen on viral expression in patients infected with human immunodeficiency virus type 1. NEW ENGLAND JOURNAL OF MEDICINE. 334(19), 1222-1230.
(1995). SYNAPTIC EXPRESSION OF THE HIGH-AFFINITY KAINATE RECEPTOR SUBUNIT KA2 IN HIPPOCAMPAL CULTURES. NEUROSCIENCE. 69(2), 383-393.
(1994). GLUTAMATE-RECEPTOR MODULATION BY PROTEIN-PHOSPHORYLATION. 88(3), 181-192.
(1994). TRANSMEMBRANE TOPOLOGY OF THE GLUTAMATE-RECEPTOR SUBUNIT GLUR6. JOURNAL OF BIOLOGICAL CHEMISTRY. 269(16), 11679-11682.
(1993). REGULATION OF NMDA RECEPTOR PHOSPHORYLATION BY ALTERNATIVE SPLICING OF THE C-TERMINAL DOMAIN. NATURE. 364(6432), 70-73.

Research Areas:

Cell Biology, Life Sciences & Biomedicine - Other Topics, Science & Technology - Other Topics, Biochemistry & Molecular Biology, Neurosciences & Neurology, Psychiatry, Pharmacology & Pharmacy

Co-author Network

Map of Science

ORCID

0000-0001-7282-6539

Research Areas:

Cell Biology, Life Sciences & Biomedicine - Other Topics, Science & Technology - Other Topics, Biochemistry & Molecular Biology, Neurosciences & Neurology, Psychiatry, Pharmacology & Pharmacy