Roche, Katherine W., Ph.D.
individual record
Senior Investigator
Positions:
- Senior Investigator, Receptor Biology Section
overview
Dr. Roche received her B.S. from Duke University. In 1995 she received her Ph.D. from Johns Hopkins University, where she worked with Richard Huganir studying the regulation of glutamate receptors. She then did a postdoctoral fellowship with Robert Wenthold in the NIDCD, where she investigated the cell biology of glutamate receptor transport and localization. Dr. Roche joined NINDS as an Investigator in 2001. The main focus of her laboratory is the study of neurotransmitter receptor expression and targeting to the synapse.
selected publications
Articles1
- (2020). A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y. NEURON. 106(5), 759-+.
Academic Articles90
- (2020). Regulation of glutamate receptors by striatal-enriched tyrosine phosphatase 61 (STEP61). JOURNAL OF PHYSIOLOGY-LONDON.
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- (2019). Isoform-specific cleavage of neuroligin-3 reduces synapse strength. MOLECULAR PSYCHIATRY. 24(1), 145-160.
- (2019). PSD-95 binding dynamically regulates NLGN1 trafficking and function. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 116(24), 12035-12044.
- (2019). Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action. Cell Reports. 29(10), 2944-+.