- Senior Investigator, Receptor Biology Section
Dr. Roche received her B.S. from Duke University. In 1995 she received her Ph.D. from Johns Hopkins University, where she worked with Richard Huganir studying the regulation of glutamate receptors. She then did a postdoctoral fellowship with Robert Wenthold in the NIDCD, where she investigated the cell biology of glutamate receptor transport and localization. Dr. Roche joined NINDS as an Investigator in 2001. The main focus of her laboratory is the study of neurotransmitter receptor expression and targeting to the synapse.
- (2019). The STEP61 interactome reveals subunit-specific AMPA receptor binding and synaptic regulation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 116(16), 8028-8037.
- (2018). Metabotropic glutamate receptor trafficking. MOLECULAR AND CELLULAR NEUROSCIENCE. 91, 10-24.
- (2018). The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms. Nature Communications. 9,
- (2017). A Rare Variant Identified Within the GluN2B C-Terminus in a Patient with Autism Affects NMDA Receptor Surface Expression and Spine Density. JOURNAL OF NEUROSCIENCE. 37(15), 4093-4102.