- Investigator, Unit on Genetics of Cognition and Behavior in the Mood and Anxiety Disorder Program
Dr. Nakazawa is chief of the Unit on Genetics of Cognition and Behavior in the Mood and Anxiety Disorder Program, National Institute of Mental Health, National Institutes of Health. Dr. Nakazawa received his Ph.D. from Keio University School of Medicine in Tokyo, Japan, investigating the elucidation of molecular diversity of glycosyltransferase families. In 1991, he began post-doctoral training in neuroscience at the Laboratory for Neural Networks, Frontier Research Programs (later joined with the Brain Science Institute) in the RIKEN Institute at Wako, Japan. During this time, his research focused on the molecular and cellular mechanisms of cerebellar long-term depression. In 1995 he moved to the Center for Learning and Memory at Massachusetts Institute of Technology (MIT) as a research fellow, and he became a research associate in 2000. While at MIT, Dr. Nakazawa developed cell type-restricted gene manipulation system in hippocampal CA3 by over-expressing Cre recombinase in transgenic mice.
Academic Articles19
- (2013). Social Isolation Exacerbates Schizophrenia-Like Phenotypes via Oxidative Stress in Cortical Interneurons. BIOLOGICAL PSYCHIATRY. 73(10), 1024-1034.
- (2012). Acute D-serine treatment produces antidepressant-like effects in rodents. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 15(8), 1135-1148.
- (2012). GABAergic interneuron origin of schizophrenia pathophysiology. NEUROPHARMACOLOGY. 62(3), 1574-1583.
- (2012). Hilar Mossy Cell Degeneration Causes Transient Dentate Granule Cell Hyperexcitability and Impaired Pattern Separation. NEURON. 76(6), 1189-1200.
- (2010). Loss of GluN2B-Containing NMDA Receptors in CA1 Hippocampus and Cortex Impairs Long-Term Depression, Reduces Dendritic Spine Density, and Disrupts Learning. JOURNAL OF NEUROSCIENCE. 30(13), 4590-4600.