- Investigator, Laboratory of Translational Genomics
Dr. Brown received a Ph.D. in genetics from the George Washington University in Washington, D.C., in 2003. He conducted his postdoctoral training in the Laboratory of Dr. Jeffrey Trent at the Translational Genomic Research Institute (TGen) in Phoenix, Arizona. He subsequently went on to direct his own research program at TGen as an investigator from 2005 to 2010, and served as an adjunct professor in basic medical sciences at the Mayo Clinic Cancer Center, the University of Arizona College of Medicine, and Arizona State University from 2008 to 2010. His work at TGen involved the application of whole-genome familial linkage, candidate gene, and genome-wide association study (GWAS) approaches to identify genetic variants associated with melanoma susceptibility. In 2010, Dr. Brown joined the Laboratory of Translational Genomics (LTG) in the Division of Cancer Epidemiology and Genetics (DCEG) as a tenure-track investigator. His research focuses on the genetic underpinnings of melanoma susceptibility.
Academic Articles280
- (2020). Diagnostic and Prognostic Biomarkers for Chronic Fibrosing Interstitial Lung Diseases With a Progressive Phenotype. CHEST. 158(2), 646-659.
- (2020). Interstitial lung abnormalities detected incidentally on CT: a Position Paper from the Fleischner Society. Lancet Respiratory Medicine. 8(7), 726-737.
- (2020). The genomic and epigenomic evolutionary history of papillary renal cell carcinomas. Nature Communications. 11(1),
- (2020). IgA Antibodies Directed Against Citrullinated Protein Antigens Are Elevated in Patients With Idiopathic Pulmonary Fibrosis. CHEST. 157(6), 1513-1521.
- (2020). Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma. Nature Communications. 11(1),
- (2020). Overlapping genetic architecture between Parkinson disease and melanoma (vol 139, pg 347, 2020). ACTA NEUROPATHOLOGICA. 139(5), 963-963.
- (2020). Clinical Decision-Making in Hypersensitivity Pneumonitis: Diagnosis and Management. SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE. 41(2), 214-228.
- (2020). Probable usual interstitial pneumonia pattern on chest CT: is it sufficient for a diagnosis of idiopathic pulmonary fibrosis?. EUROPEAN RESPIRATORY JOURNAL. 55(4),
- (2020). Nintedanib in Progressive Fibrosing Interstitial Lung Diseases Reply. NEW ENGLAND JOURNAL OF MEDICINE. 382(8), 781-781.
- (2020). Overlapping genetic architecture between Parkinson disease and melanoma. ACTA NEUROPATHOLOGICA. 139(2), 347-364.
- (2020). Lung Hyperlucency A Clinical-Radiologic Algorithmic Approach to Diagnosis. CHEST. 157(1), 119-141.
- (2020). Risk factors for disease progression in idiopathic pulmonary fibrosis. THORAX. 75(1), 78-80.
- (2019). A Dynamic Cis-Regulation Pattern Underlying Epithelial Ovarian Cancer Susceptibility. CANCER RESEARCH. 79(3), 439-440.
- (2019). Computed Tomographic Biomarkers in Idiopathic Pulmonary Fibrosis The Future of Quantitative Analysis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 199(1), 12-21.
- (2019). Diagnostic Likelihood Thresholds That Define a Working Diagnosis of Idiopathic Pulmonary Fibrosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 200(9), 1146-1153.
- (2019). Evaluation of the contribution of germline variants in BRCA1 and BRCA2 to uveal and cutaneous melanoma. MELANOMA RESEARCH. 29(5), 483-490.
- (2019). Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses. Cell Reports. 29(3), 573-+.
- (2019). Increasing Hypersensitivity Pneumonitis-related Mortality in the United States from 1988 to 2016. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 199(10), 1284-1287.
- (2019). Interstitial lung disease associated with systemic sclerosis (SSc-ILD). RESPIRATORY RESEARCH. 20,
- (2019). Lung function outcomes in the INPULSIS (R) trials of nintedanib in idiopathic pulmonary fibrosis. RESPIRATORY MEDICINE. 146, 42-48.
- (2019). MUC5B variant is associated with visually and quantitatively detected preclinical pulmonary fibrosis. THORAX. 74(12), 1131-1139.