Scholars

Investigator

Positions:

Investigator, Laboratory of Translational Genomics

Research Areas:

Research & Experimental Medicine, Cell Biology, Dermatology, Genetics & Heredity, General & Internal Medicine, Science & Technology - Other Topics, Oncology, Biochemistry & Molecular Biology, Cardiovascular System & Cardiology, Medical Laboratory Technology, Respiratory System, Pathology

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overview

Dr. Brown received a Ph.D. in genetics from the George Washington University in Washington, D.C., in 2003. He conducted his postdoctoral training in the Laboratory of Dr. Jeffrey Trent at the Translational Genomic Research Institute (TGen) in Phoenix, Arizona. He subsequently went on to direct his own research program at TGen as an investigator from 2005 to 2010, and served as an adjunct professor in basic medical sciences at the Mayo Clinic Cancer Center, the University of Arizona College of Medicine, and Arizona State University from 2008 to 2010. His work at TGen involved the application of whole-genome familial linkage, candidate gene, and genome-wide association study (GWAS) approaches to identify genetic variants associated with melanoma susceptibility. In 2010, Dr. Brown joined the Laboratory of Translational Genomics (LTG) in the Division of Cancer Epidemiology and Genetics (DCEG) as a tenure-track investigator. His research focuses on the genetic underpinnings of melanoma susceptibility.

selected publications

Academic Articles280

(2020). Diagnostic and Prognostic Biomarkers for Chronic Fibrosing Interstitial Lung Diseases With a Progressive Phenotype. CHEST. 158(2), 646-659.
(2020). Interstitial lung abnormalities detected incidentally on CT: a Position Paper from the Fleischner Society. Lancet Respiratory Medicine. 8(7), 726-737.
(2020). The genomic and epigenomic evolutionary history of papillary renal cell carcinomas. Nature Communications. 11(1),
(2020). IgA Antibodies Directed Against Citrullinated Protein Antigens Are Elevated in Patients With Idiopathic Pulmonary Fibrosis. CHEST. 157(6), 1513-1521.
(2020). Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma. Nature Communications. 11(1),
(2020). Nintedanib in patients with progressive fibrosing interstitial lung diseases-subgroup analyses by interstitial lung disease diagnosis in the INBUILD trial: a randomised, double-blind, placebo-controlled, parallel-group trial. Lancet Respiratory Medicine. 8(5), 453-460.
(2020). Overlapping genetic architecture between Parkinson disease and melanoma (vol 139, pg 347, 2020). ACTA NEUROPATHOLOGICA. 139(5), 963-963.
(2020). Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility. NATURE GENETICS. 52(5), 494-+.
(2020). Clinical Decision-Making in Hypersensitivity Pneumonitis: Diagnosis and Management. SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE. 41(2), 214-228.
(2020). Probable usual interstitial pneumonia pattern on chest CT: is it sufficient for a diagnosis of idiopathic pulmonary fibrosis?. EUROPEAN RESPIRATORY JOURNAL. 55(4),
(2020). Analysis of DNA methylation patterns in the tumor immune microenvironment of metastatic melanoma. 14(5), 933-950.
(2020). Nintedanib in Progressive Fibrosing Interstitial Lung Diseases Reply. NEW ENGLAND JOURNAL OF MEDICINE. 382(8), 781-781.
(2020). Overlapping genetic architecture between Parkinson disease and melanoma. ACTA NEUROPATHOLOGICA. 139(2), 347-364.
(2020). Lung Hyperlucency A Clinical-Radiologic Algorithmic Approach to Diagnosis. CHEST. 157(1), 119-141.
(2020). Risk factors for disease progression in idiopathic pulmonary fibrosis. THORAX. 75(1), 78-80.
(2019). A Dynamic Cis-Regulation Pattern Underlying Epithelial Ovarian Cancer Susceptibility. CANCER RESEARCH. 79(3), 439-440.
(2019). Computed Tomographic Biomarkers in Idiopathic Pulmonary Fibrosis The Future of Quantitative Analysis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 199(1), 12-21.
(2019). Diagnostic Likelihood Thresholds That Define a Working Diagnosis of Idiopathic Pulmonary Fibrosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 200(9), 1146-1153.
(2019). Evaluation of the contribution of germline variants in BRCA1 and BRCA2 to uveal and cutaneous melanoma. MELANOMA RESEARCH. 29(5), 483-490.
(2019). Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses. Cell Reports. 29(3), 573-+.
(2019). Increasing Hypersensitivity Pneumonitis-related Mortality in the United States from 1988 to 2016. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 199(10), 1284-1287.
(2019). Interstitial lung disease associated with systemic sclerosis (SSc-ILD). RESPIRATORY RESEARCH. 20,
(2019). Lung function outcomes in the INPULSIS (R) trials of nintedanib in idiopathic pulmonary fibrosis. RESPIRATORY MEDICINE. 146, 42-48.
(2019). MUC5B variant is associated with visually and quantitatively detected preclinical pulmonary fibrosis. THORAX. 74(12), 1131-1139.
(2019). Meta-analysis of GWA studies provides new insights on the genetic architecture of skin pigmentation in recently admixed populations. BMC GENETICS. 20,
(2019). Modelling Forced Vital Capacity in Idiopathic Pulmonary Fibrosis: Optimising Trial Design. ADVANCES IN THERAPY. 36(11), 3059-3070.
(2019). Nintedanib in Progressive Fibrosing Interstitial Lung Diseases. NEW ENGLAND JOURNAL OF MEDICINE. 381(18), 1718-1727.
(2019). Proceedings of the American College of Rheumatology/Association of Physicians of Great Britain and Ireland Connective Tissue Disease-Associated Interstitial Lung Disease Summit: A Multidisciplinary Approach to Address Challenges and Opportunities. Arthritis & Rheumatology. 71(2), 182-195.
(2019). Proceedings of the American College of Rheumatology/Association of Physicians of Great Britain and Ireland Connective Tissue Disease-Associated Interstitial Lung Disease Summit: A Multidisciplinary Approach to Address Challenges and Opportunities. QJM-AN INTERNATIONAL JOURNAL OF MEDICINE. 112(2), 81-93.
(2019). Pulmonary fibrosis: "idiopathic" is not "cryptogenic". EUROPEAN RESPIRATORY JOURNAL. 53(3),
(2019). Rationale, design and objectives of two phase III, randomised, placebo-controlled studies of GLPG1690, a novel autotaxin inhibitor, in idiopathic pulmonary fibrosis (ISABELA 1 and 2). BMJ Open Respiratory Research. 6(1),
(2019). Research in Pulmonary Fibrosis Across Species: Unleashing Discovery Through Comparative Biology. AMERICAN JOURNAL OF THE MEDICAL SCIENCES. 357(5), 399-404.
(2019). Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 200(2), 199-208.
(2019). Sex specific associations in genome wide association analysis of renal cell carcinoma. EUROPEAN JOURNAL OF HUMAN GENETICS. 27(10), 1589-1598.
(2019). The Fibrosis Across Organs Symposium: A Roadmap for Future Research Priorities. AMERICAN JOURNAL OF THE MEDICAL SCIENCES. 357(5), 405-410.
(2019). The NHLBI LAM Registry Prognostic Physiologic and Radiologic Biomarkers Emerge From a 15-Year Prospective Longitudinal Analysis. CHEST. 155(2), 288-296.
(2019). The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study. PLOS MEDICINE. 16(1),
(2019). Untitled. EUROPEAN RESPIRATORY JOURNAL. 53(2),
(2019). Use of a molecular classifier to identify usual interstitial pneumonia in conventional transbronchial lung biopsy samples: a prospective validation study. Lancet Respiratory Medicine. 7(6), 487-496.
(2019). Which Biopsy to Diagnose Interstitial Lung Disease? A Call for Evidence and Unity. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 200(7), 941-942.
(2018). Analysis of NRAS gain in 657 patients with melanoma and evaluation of its sensitivity to a MEK inhibitor. EUROPEAN JOURNAL OF CANCER. 89, 90-101.
(2018). Assessing the Incremental Contribution of Common Genomic Variants to Melanoma Risk Prediction in Two Population-Based Studies. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 138(12), 2617-2624.
(2018). Cell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes. GENOME RESEARCH. 28(11), 1621-1635.
(2018). Characterising cis-regulatory variation in the transcriptome of histologically normal and tumour-derived pancreatic tissues. GUT. 67(3), 521-533.
(2018). Combining common genetic variants and non-genetic risk factors to predict risk of cutaneous melanoma. HUMAN MOLECULAR GENETICS. 27(23), 4145-4156.
(2018). Diagnosis of Idiopathic Pulmonary Fibrosis An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 198(5), E44-E68.
(2018). Diagnostic criteria for idiopathic pulmonary fibrosis: a Fleischner Society White Paper. Lancet Respiratory Medicine. 6(2), 138-153.
(2018). Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma (vol 72, pg 747, 2017). EUROPEAN UROLOGY. 74(3), E84-E85.
(2018). Patients' perceptions and patient reported outcomes in progressive-fibrosing interstitial lung diseases. European Respiratory Review. 27(150),
(2018). Psychometric properties of the St George's Respiratory Questionnaire in patients with idiopathic pulmonary fibrosis: insights from the INPULSIS trials. BMJ Open Respiratory Research. 5(1),

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Academic Articles280