- Senior Investigator, Laboratory of Cellular and Molecular Biology
Dr. Samelson received his M.D. degree from Yale University in 1977. Following training in internal medicine at the University of Chicago, he carried out postdoctoral research at the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases. He joined the Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development in 1985, became senior investigator in 1988, and chief of the Section on Lymphocyte Signaling and deputy branch chief in 1995. He became chief of the Laboratory of Cellular and Molecular Biology, NCI, in 1999.
- (2019). Pak1 Kinase Promotes Activated T Cell Trafficking by Regulating the Expression of L-Selectin and. Frontiers in Immunology. 10,
- (2019). TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps. Nature Communications. 10,
- (2018). Cooperative assembly of a four-molecule signaling complex formed upon T cell antigen receptor activation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 115(51), E11914-E11923.
- (2018). Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70(T293) and destabilization of the signalosome. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 115(9), 2174-2179.
- (2018). Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation. Nature Communications. 9,
- (2018). The Cish SH2 domain is essential for PLC-gamma 1 regulation in TCR stimulated CD8(+) T cells. Scientific Reports. 8,
- (2018). Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8(+) T Cell Expansion and Differentiation. Cell Reports. 24(5), 1123-1135.
- (2017). Highly Multiplexed, Super-resolution Imaging of T Cells Using madSTORM. Jove-Journal of Visualized Experiments. (124),
- (2017). Recruitment of calcineurin to the TCR positively regulates T cell activation. NATURE IMMUNOLOGY. 18(2), 196-204.