Samelson, Lawrence E., M.D.
individual record
Senior Investigator
Positions:
- Senior Investigator, Laboratory of Cellular and Molecular Biology
overview
Dr. Samelson received his M.D. degree from Yale University in 1977. Following training in internal medicine at the University of Chicago, he carried out postdoctoral research at the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases. He joined the Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development in 1985, became senior investigator in 1988, and chief of the Section on Lymphocyte Signaling and deputy branch chief in 1995. He became chief of the Laboratory of Cellular and Molecular Biology, NCI, in 1999.
selected publications
Academic Articles193
- (2019). Pak1 Kinase Promotes Activated T Cell Trafficking by Regulating the Expression of L-Selectin and. Frontiers in Immunology. 10,
- (2019). TCR microclusters form spatially segregated domains and sequentially assemble in calcium-dependent kinetic steps. Nature Communications. 10,
- (2018). Cooperative assembly of a four-molecule signaling complex formed upon T cell antigen receptor activation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 115(51), E11914-E11923.
- (2018). Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70(T293) and destabilization of the signalosome. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 115(9), 2174-2179.
- (2018). Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation. Nature Communications. 9,
- (2018). The Cish SH2 domain is essential for PLC-gamma 1 regulation in TCR stimulated CD8(+) T cells. Scientific Reports. 8,
- (2018). Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8(+) T Cell Expansion and Differentiation. Cell Reports. 24(5), 1123-1135.
- (2017). Highly Multiplexed, Super-resolution Imaging of T Cells Using madSTORM. Jove-Journal of Visualized Experiments. (124),
- (2017). Recruitment of calcineurin to the TCR positively regulates T cell activation. NATURE IMMUNOLOGY. 18(2), 196-204.
- (2017). Unexpected Cartilage Phenotype in CD4-Cre-Conditional SOS-Deficient Mice. Frontiers in Immunology. 8,
- (2016). Development of nanoscale structure in LAT-based signaling complexes. JOURNAL OF CELL SCIENCE. 129(24), 4548-4562.
- (2016). Hierarchical nanostructure and synergy of multimolecular signalling complexes. Nature Communications. 7,
- (2016). Microvilli set the stage for T-cell activation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 113(40), 11061-11062.
- (2016). madSTORM: a superresolution technique for large-scale multiplexing at single-molecule accuracy. MOLECULAR BIOLOGY OF THE CELL. 27(22), 3591-3600.
- (2015). Absence of both Sos-1 and Sos-2 in peripheral CD4+T cells leads to PI3K pathway activation and defects in migration. EUROPEAN JOURNAL OF IMMUNOLOGY. 45(8), 2389-2395.
- (2015). Cish actively silences TCR signaling in CD8(+) T cells to maintain tumor tolerance. JOURNAL OF EXPERIMENTAL MEDICINE. 212(12), 2095-2113.
- (2015). Cytoskeletal forces during signaling activation in Jurkat T-cells. MOLECULAR BIOLOGY OF THE CELL. 26(4), 685-695.
- (2015). Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules. GENE THERAPY. 22(10), 781-792.
- (2015). The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters. JOURNAL OF BIOLOGICAL CHEMISTRY. 290(44), 26422-26429.
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- (2014). In vivo functional mapping of the conserved protein domains within murine Themis1. IMMUNOLOGY AND CELL BIOLOGY. 92(8), 721-728.
- (2013). A Phospholipase C-gamma 1-Independent, RasGRP1-ERK-Dependent Pathway Drives Lymphoproliferative Disease in Linker for Activation of T Cells-Y136F Mutant Mice. JOURNAL OF IMMUNOLOGY. 190(1), 147-158.
- (2013). Automatic sorting of point pattern sets using Minkowski functionals. PHYSICAL REVIEW E. 88(2),
- (2013). Cutting Edge: Cell Surface Linker for Activation of T Cells Is Recruited to Microclusters and Is Active in Signaling. JOURNAL OF IMMUNOLOGY. 190(8), 3849-3853.
- (2013). Enhanced Function of Redirected Human T Cells Expressing Linker for Activation of T Cells That Is Resistant to Ubiquitylation. HUMAN GENE THERAPY. 24(1), 27-37.
- (2013). Functional Redundancy of Sos1 and Sos2 for Lymphopoiesis and Organismal Homeostasis and Survival. MOLECULAR AND CELLULAR BIOLOGY. 33(22), 4562-4578.
- (2013). Multipoint Binding of the SLP-76 SH2 Domain to ADAP Is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T Cells. MOLECULAR AND CELLULAR BIOLOGY. 33(21), 4140-4151.
- (2013). Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells. TRENDS IN IMMUNOLOGY. 34(6), 259-268.
- (2013). Resolving multi-molecular protein interactions by photoactivated localization microscopy. METHODS. 59(3), 261-269.
- (2013). Super-resolution characterization of TCR-dependent signaling clusters. IMMUNOLOGICAL REVIEWS. 251, 21-35.
- (2013). The Ability of Sos1 to Oligomerize the Adaptor Protein LAT Is Separable from Its Guanine Nucleotide Exchange Activity in Vivo. Science Signaling. 6(301),
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- (2012). Deconstructing Ras Signaling in the Thymus. MOLECULAR AND CELLULAR BIOLOGY. 32(14), 2748-2759.
- (2012). Interchangeability of Themis1 and Themis2 in Thymocyte Development Reveals Two Related Proteins with Conserved Molecular Function. JOURNAL OF IMMUNOLOGY. 189(3), 1154-1161.
- (2012). LAT-Independent Erk Activation via Bam32-PLC-gamma 1-Pak1 Complexes: GTPase-Independent Pak1 Activation. MOLECULAR CELL. 48(2), 298-312.
- (2011). Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 108(7), 2885-2890.
- (2011). Functional Nanoscale Organization of Signaling Molecules Downstream of the T Cell Antigen Receptor. IMMUNITY. 35(5), 705-720.
- (2011). Imaging techniques for assaying lymphocyte activation in action. NATURE REVIEWS IMMUNOLOGY. 11(1), 21-33.
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- (2011). Targeted Sos1 deletion reveals its critical role in early T-cell development. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 108(30), 12407-12412.
- (2010). Cooperative interactions at the SLP-76 complex are critical for actin polymerization. EMBO JOURNAL. 29(14), 2315-2328.
- (2010). The LAT Story: A Tale of Cooperativity, Coordination, and Choreography. Cold Spring Harbor Perspectives in Biology. 2(8),
- (2009). Endocytic events in TCR signaling: focus on adapters in microclusters. IMMUNOLOGICAL REVIEWS. 232, 84-98.
- (2009). Formation of STIM and Orai complexes: puncta and distal caps. IMMUNOLOGICAL REVIEWS. 231, 148-159.
- (2009). Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 106(34), 14502-14507.
- (2009). Priming the Pump: Adhesion Enhances T Cell Antigen Receptor-Induced Signaling. IMMUNITY. 30(1), 3-5.
- (2008). Bam32: a novel mediator of Erk activation in T cells. INTERNATIONAL IMMUNOLOGY. 20(7), 811-818.