- Senior Investigator, Laboratory of Cellular and Molecular Biology
Dr. Samelson received his M.D. degree from Yale University in 1977. Following training in internal medicine at the University of Chicago, he carried out postdoctoral research at the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases. He joined the Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development in 1985, became senior investigator in 1988, and chief of the Section on Lymphocyte Signaling and deputy branch chief in 1995. He became chief of the Laboratory of Cellular and Molecular Biology, NCI, in 1999.
- (2015). Absence of both Sos-1 and Sos-2 in peripheral CD4+T cells leads to PI3K pathway activation and defects in migration. EUROPEAN JOURNAL OF IMMUNOLOGY. 45(8), 2389-2395.
- (2015). Cish actively silences TCR signaling in CD8(+) T cells to maintain tumor tolerance. JOURNAL OF EXPERIMENTAL MEDICINE. 212(12), 2095-2113.
- (2015). Cytoskeletal forces during signaling activation in Jurkat T-cells. MOLECULAR BIOLOGY OF THE CELL. 26(4), 685-695.
- (2015). Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules. GENE THERAPY. 22(10), 781-792.
- (2015). The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters. JOURNAL OF BIOLOGICAL CHEMISTRY. 290(44), 26422-26429.