- Senior Investigator, Section on Membrane Biology
Dr. Leonid Chernomordik was awarded a Ph.D. in 1979 from the Frumkin Institute of Electrochemistry, Russian Academy of Sciences and a Doctor of Sciences in 1991 from Moscow State University; the latter is the highest academic status degree in Russia, roughly equivalent to a full professorship. In 1991, after 15 years of research in the Frumkin Institute of Electrochemistry, Dr. Chernomordik joined NICHD, where he leads the Section on Membrane Biology. Dr. Chernomordik’s area of speciality is biomembrane structure and cell function and work at the intersection of cell biology, virology and biophysics. His laboratory’s work on membrane fusion has identified the conserved pathway of membrane remodeling that underlies fundamental processes as diverse and important as viral infections, exocytosis and fertilization. Current work of the Section of Membrane Biology concentrates on mechanisms by which enveloped viruses enter cells and on cell to cell fusion in development. The hope is that identification of the molecular mechanisms of membrane remodeling will help in developing new ways of controlling cell fusion and intracellular fusion throughout normal development of many human organs and tissues and in many genetic and infectious diseases.
- (2013). Mechanistic Study of Broadly Neutralizing Human Monoclonal Antibodies against Dengue Virus That Target the Fusion Loop. JOURNAL OF VIROLOGY. 87(1), 52-66.
- (2012). Structural insights into the neutralization mechanism of a higher primate antibody against dengue virus. EMBO JOURNAL. 31(3), 767-779.
- (2011). Intracellular curvature-generating proteins in cell-to-cell fusion. BIOCHEMICAL JOURNAL. 440, 185-193.
- (2011). The Final Conformation of the Complete Ectodomain of the HA2 Subunit of Influenza Hemagglutinin Can by Itself Drive Low pH-dependent Fusion. JOURNAL OF BIOLOGICAL CHEMISTRY. 286(15), 13226-13234.
- (2010). Cell-Penetrating Peptide Induces Leaky Fusion of Liposomes Containing Late Endosome-Specific Anionic Lipid. BIOPHYSICAL JOURNAL. 99(8), 2525-2533.