- Senior Investigator, Section on Membrane Biology
Dr. Leonid Chernomordik was awarded a Ph.D. in 1979 from the Frumkin Institute of Electrochemistry, Russian Academy of Sciences and a Doctor of Sciences in 1991 from Moscow State University; the latter is the highest academic status degree in Russia, roughly equivalent to a full professorship. In 1991, after 15 years of research in the Frumkin Institute of Electrochemistry, Dr. Chernomordik joined NICHD, where he leads the Section on Membrane Biology. Dr. Chernomordik’s area of speciality is biomembrane structure and cell function and work at the intersection of cell biology, virology and biophysics. His laboratory’s work on membrane fusion has identified the conserved pathway of membrane remodeling that underlies fundamental processes as diverse and important as viral infections, exocytosis and fertilization. Current work of the Section of Membrane Biology concentrates on mechanisms by which enveloped viruses enter cells and on cell to cell fusion in development. The hope is that identification of the molecular mechanisms of membrane remodeling will help in developing new ways of controlling cell fusion and intracellular fusion throughout normal development of many human organs and tissues and in many genetic and infectious diseases.
- (2019). How cells fuse. JOURNAL OF CELL BIOLOGY. 218(5), 1436-1451.
- (2019). Interactions with Muscle Cells Boost Fusion, Stemness, and Drug Resistance of Prostate Cancer Cells. MOLECULAR CANCER RESEARCH. 17(3), 806-820.
- (2019). Syncytin 1 dependent horizontal transfer of marker genes from retrovirally transduced cells. Scientific Reports. 9,
- (2018). An improved metrics for osteoclast multinucleation. Scientific Reports. 8,
- (2018). Cell-surface phosphatidylserine regulates osteoclast precursor fusion. 293(1), 254-270.
- (2018). Myomaker and Myomerger Work Independently to Control Distinct Steps of Membrane Remodeling during Myoblast Fusion. DEVELOPMENTAL CELL. 46(6), 767-+.
- (2017). Arabidopsis HAP2/GCS1 is a gamete fusion protein homologous to somatic and viral fusogens. JOURNAL OF CELL BIOLOGY. 216(3), 571-581.
- (2017). Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine. Cell Host & Microbe. 22(1), 99-+.
- (2017). Insights into the localization and function of myomaker during myoblast fusion. JOURNAL OF BIOLOGICAL CHEMISTRY. 292(42), 17272-17289.
- (2016). Evaluation of the maturation of individual Dengue virions with flow virometry. VIROLOGY. 488, 20-27.