Scholars

Gottesman, Michael M., M.D.

Senior Investigator

Positions:

Senior Investigator, Laboratory of Cell Biology

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overview

Dr. Gottesman obtained his M.D. from Harvard University Medical School, completed his internship and residency in medicine at the Peter Bent Brigham Hospital in Boston, and received his postdoctoral research training in molecular genetics with Martin Gellert at the NIH. After a year as an assistant professor in the Department of Anatomy at Harvard, he moved to the NIH in 1976. He currently serves as the NIH deputy director for intramural research as well as chief of the Laboratory of Cell Biology.

selected publications

Articles1

(1981). INVITRO ASSEMBLY OF HOMOPOLYMER AND CO-POLYMER FILAMENTS FROM INTERMEDIATE FILAMENT SUBUNITS OF MUSCLE AND FIBROBLASTIC CELLS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 78(6), 3692-3696.

Academic Articles500

(2020). Leptin Signaling Affects Survival and Chemoresistance of Estrogen Receptor Negative Breast Cancer. 21(11),
(2020). Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin (vol 289, pg 21473, 2014). JOURNAL OF BIOLOGICAL CHEMISTRY. 295(13), 4370-4370.
(2020). A role for ceramide glycosylation in resistance to oxaliplatin in colorectal cancer. EXPERIMENTAL CELL RESEARCH. 388(2),
(2020). Collateral Sensitivity of Multidrug-Resistant Cells to the Orphan Drug Tiopronin (Retraction of Vol 54, Pg 4987, 2011). JOURNAL OF MEDICINAL CHEMISTRY. 63(3), 1443-1443.
(2020). Mycoplasma Infection Mediates Sensitivity of Multidrug-Resistant Cell Lines to Tiopronin: A Cautionary Tale. JOURNAL OF MEDICINAL CHEMISTRY. 63(3), 1434-1439.
(2020). The Evolving AML Genomic Landscape: Therapeutic Implications. CURRENT CANCER DRUG TARGETS. 20(7), 532-544.
(2019). Coexpression of ABCB1 and ABCG2 in a Cell Line Model Reveals Both Independent and Additive Transporter Function. DRUG METABOLISM AND DISPOSITION. 47(7), 715-723.
(2019). Heterogeneity in refractory acute myeloid leukemia. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 116(21), 10494-10503.
(2019). Model systems for studying the blood-brain barrier: Applications and challenges. BIOMATERIALS. 214,
(2019). Porphyrin-lipid assemblies and nanovesicles overcome ABC transporter-mediated photodynamic therapy resistance in cancer cells. CANCER LETTERS. 457, 110-118.
(2019). Racial profiling harms science Response. SCIENCE. 363(6433), 1291-1294.
(2019). Spatial control of oxygen delivery to three-dimensional cultures alters cancer cell growth and gene expression. JOURNAL OF CELLULAR PHYSIOLOGY. 234(11), 20608-20622.
(2019). Targeting mitochondrial hexokinases increases efficacy of histone deacetylase inhibitors in solid tumor models. EXPERIMENTAL CELL RESEARCH. 375(2), 106-112.
(2018). Mapping discontinuous epitopes for MRK-16, UIC2 and 4E3 antibodies to extracellular loops 1 and 4 of human P-glycoprotein. Scientific Reports. 8,
(2018). Pluripotent Stem Cell Platforms for Drug Discovery. TRENDS IN MOLECULAR MEDICINE. 24(9), 805-820.
(2018). Revisiting the role of ABC transporters in multidrug-resistant cancer. NATURE REVIEWS CANCER. 18(7), 452-464.
(2018). The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding. JOURNAL OF BIOLOGICAL CHEMISTRY. 293(42), 16142-16159.
(2017). An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 37(6), 2062-2075.
(2017). Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. JOURNAL OF BIOLOGICAL CHEMISTRY. 292(2), 446-461.
(2016). A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy. MOLECULAR PHARMACOLOGY. 89(2), 263-272.
(2016). Basic science: Bedrock of progress. SCIENCE. 351(6280), 1405-1405.
(2016). Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier. Scientific Reports. 6,
(2016). Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras. 7(43), 69804-69815.
(2016). Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle. MOLECULAR PHARMACOLOGY. 90(1), 35-41.
(2016). F-18-FCWAY, a serotonin 1A receptor radioligand, is a substrate for efflux transport at the human blood-brain barrier. NEUROIMAGE. 138, 134-140.

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