Scholars

Gottesman, Michael M., M.D.

Senior Investigator

Positions:

Senior Investigator, Laboratory of Cell Biology

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overview

Dr. Gottesman obtained his M.D. from Harvard University Medical School, completed his internship and residency in medicine at the Peter Bent Brigham Hospital in Boston, and received his postdoctoral research training in molecular genetics with Martin Gellert at the NIH. After a year as an assistant professor in the Department of Anatomy at Harvard, he moved to the NIH in 1976. He currently serves as the NIH deputy director for intramural research as well as chief of the Laboratory of Cell Biology.

selected publications

Articles1

(1981). INVITRO ASSEMBLY OF HOMOPOLYMER AND CO-POLYMER FILAMENTS FROM INTERMEDIATE FILAMENT SUBUNITS OF MUSCLE AND FIBROBLASTIC CELLS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 78(6), 3692-3696.

Academic Articles500

(2020). Leptin Signaling Affects Survival and Chemoresistance of Estrogen Receptor Negative Breast Cancer. 21(11),
(2020). Inhibition of glutathione peroxidase mediates the collateral sensitivity of multidrug-resistant cells to tiopronin (vol 289, pg 21473, 2014). JOURNAL OF BIOLOGICAL CHEMISTRY. 295(13), 4370-4370.
(2020). A role for ceramide glycosylation in resistance to oxaliplatin in colorectal cancer. EXPERIMENTAL CELL RESEARCH. 388(2),
(2020). Collateral Sensitivity of Multidrug-Resistant Cells to the Orphan Drug Tiopronin (Retraction of Vol 54, Pg 4987, 2011). JOURNAL OF MEDICINAL CHEMISTRY. 63(3), 1443-1443.
(2020). Mycoplasma Infection Mediates Sensitivity of Multidrug-Resistant Cell Lines to Tiopronin: A Cautionary Tale. JOURNAL OF MEDICINAL CHEMISTRY. 63(3), 1434-1439.
(2020). The Evolving AML Genomic Landscape: Therapeutic Implications. CURRENT CANCER DRUG TARGETS. 20(7), 532-544.
(2019). Coexpression of ABCB1 and ABCG2 in a Cell Line Model Reveals Both Independent and Additive Transporter Function. DRUG METABOLISM AND DISPOSITION. 47(7), 715-723.
(2019). Heterogeneity in refractory acute myeloid leukemia. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 116(21), 10494-10503.
(2019). Model systems for studying the blood-brain barrier: Applications and challenges. BIOMATERIALS. 214,
(2019). Porphyrin-lipid assemblies and nanovesicles overcome ABC transporter-mediated photodynamic therapy resistance in cancer cells. CANCER LETTERS. 457, 110-118.
(2019). Racial profiling harms science Response. SCIENCE. 363(6433), 1291-1294.
(2019). Spatial control of oxygen delivery to three-dimensional cultures alters cancer cell growth and gene expression. JOURNAL OF CELLULAR PHYSIOLOGY. 234(11), 20608-20622.
(2019). Targeting mitochondrial hexokinases increases efficacy of histone deacetylase inhibitors in solid tumor models. EXPERIMENTAL CELL RESEARCH. 375(2), 106-112.
(2018). Mapping discontinuous epitopes for MRK-16, UIC2 and 4E3 antibodies to extracellular loops 1 and 4 of human P-glycoprotein. Scientific Reports. 8,
(2018). Pluripotent Stem Cell Platforms for Drug Discovery. TRENDS IN MOLECULAR MEDICINE. 24(9), 805-820.
(2018). Revisiting the role of ABC transporters in multidrug-resistant cancer. NATURE REVIEWS CANCER. 18(7), 452-464.
(2018). The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding. JOURNAL OF BIOLOGICAL CHEMISTRY. 293(42), 16142-16159.
(2017). An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 37(6), 2062-2075.
(2017). Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. JOURNAL OF BIOLOGICAL CHEMISTRY. 292(2), 446-461.
(2016). A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy. MOLECULAR PHARMACOLOGY. 89(2), 263-272.
(2016). Basic science: Bedrock of progress. SCIENCE. 351(6280), 1405-1405.
(2016). Bioluminescent imaging of ABCG2 efflux activity at the blood-placenta barrier. Scientific Reports. 6,
(2016). Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras. 7(43), 69804-69815.
(2016). Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle. MOLECULAR PHARMACOLOGY. 90(1), 35-41.
(2016). F-18-FCWAY, a serotonin 1A receptor radioligand, is a substrate for efflux transport at the human blood-brain barrier. NEUROIMAGE. 138, 134-140.
(2016). Human-Mouse Chimeras with Normal Expression and Function Reveal That Major Domain Swapping Is Tolerated by P-Glycoprotein (ABCB1). BIOCHEMISTRY. 55(7), 1010-1023.
(2016). In Vivo Bioluminescent Imaging of ATP-Binding Cassette Transporter-Mediated Efflux at the Blood-Brain Barrier..
(2016). Mathematical Modeling Reveals That Changes to Local Cell Density Dynamically Modulate Baseline Variations in Cell Growth and Drug Response. CANCER RESEARCH. 76(10), 2882-2890.
(2016). Outcomes From the NIH Clinical Research Training Program: A Mentored Research Experience to Enhance Career Development of Clinician-Scientists. ACADEMIC MEDICINE. 91(12), 1684-1690.
(2016). Tariquidar Is an Inhibitor and Not a Substrate of Human and Mouse P-glycoprotein. DRUG METABOLISM AND DISPOSITION. 44(2), 275-282.
(2016). The Drug Excipient Cyclodextrin Interacts With D-Luciferin and Interferes With Bioluminescence Imaging. Molecular Imaging. 15,
(2016). Toward a Better Understanding of the Complexity of Cancer Drug Resistance. Annual Review of Pharmacology and Toxicology. 56, 85-102.
(2016). Using the BacMam Baculovirus System to Study Expression and Function of Recombinant Efflux Drug Transporters in Polarized Epithelial Cell Monolayers. DRUG METABOLISM AND DISPOSITION. 44(2), 180-188.
(2015). Beyond 3D culture models of cancer. Science Translational Medicine. 7(283),
(2015). Evaluation of fluorophore-tethered platinum complexes to monitor the fate of cisplatin analogs. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 20(7), 1081-1095.
(2015). Expression of the multidrug transporter P-glycoprotein is inversely related to that of apoptosis-associated endogenous TRAIL. EXPERIMENTAL CELL RESEARCH. 336(2), 318-328.
(2015). Identification of a Cryptic Bacterial Promoter in Mouse (mdr1a) P-Glycoprotein cDNA. PLoS One. 10(8),
(2015). Modeling intrinsic heterogeneity and growth of cancer cells. JOURNAL OF THEORETICAL BIOLOGY. 367, 262-277.
(2015). Reduced accumulation of platinum drugs is not observed in drug-resistant ovarian cancer cell lines derived from cisplatin-treated patients. JOURNAL OF INORGANIC BIOCHEMISTRY. 149, 45-48.
(2015). SCORHE: A novel and practical approach to video monitoring of laboratory mice housed in vivarium cage racks. Behavior Research Methods. 47(1), 235-250.
(2015). The Inhibitor Ko143 Is Not Specific for ABCG2. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 354(3), 384-393.
(2015). The Protein Phosphatase 2A Inhibitor LB100 Sensitizes Ovarian Carcinoma Cells to Cisplatin-Mediated Cytotoxicity. MOLECULAR CANCER THERAPEUTICS. 14(1), 90-100.
(2015). The Role of Abcb5 Alleles in Susceptibility to Haloperidol-Induced Toxicity in Mice and Humans. PLOS MEDICINE. 12(2),
(2015). The Role of Multidrug Resistance Efflux Pumps in Cancer: Revisiting a JNCI Publication Exploring Expression of the MDR1 (P-glycoprotein) Gene. JNCI-Journal of the National Cancer Institute. 107(9),
(2014). Collateral Sensitivity to Cisplatin in KB-8-5-11 Drug-resistant Cancer Cells. ANTICANCER RESEARCH. 34(1B), 503-507.
(2014). Drug Resistance Is Conferred on the Model Yeast Saccharomyces cerevisiae by Expression of Full-Length Melanoma-Associated Human ATP-Binding Cassette Transporter ABCB5. MOLECULAR PHARMACEUTICS. 11(10), 3452-3462.
(2014). Gil Ashwell, 1916-2014. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 111(46), 16232-16233.
(2014). Inhibition of Glutathione Peroxidase Mediates the Collateral Sensitivity of Multidrug-resistant Cells to Tiopronin. JOURNAL OF BIOLOGICAL CHEMISTRY. 289(31), 21473-21489.
(2014). MDR1 Synonymous Polymorphisms Alter Transporter Specificity and Protein Stability in a Stable Epithelial Monolayer. CANCER RESEARCH. 74(2), 598-608.
(2014). Network features suggest new hepatocellular carcinoma treatment strategies. BMC Systems Biology. 8,

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