Scholars

Gottesman, Michael M., M.D.

Senior Investigator

Positions:

Senior Investigator, Laboratory of Cell Biology

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Dr. Gottesman obtained his M.D. from Harvard University Medical School, completed his internship and residency in medicine at the Peter Bent Brigham Hospital in Boston, and received his postdoctoral research training in molecular genetics with Martin Gellert at the NIH. After a year as an assistant professor in the Department of Anatomy at Harvard, he moved to the NIH in 1976. He currently serves as the NIH deputy director for intramural research as well as chief of the Laboratory of Cell Biology.

selected publications

Articles1

(1981). INVITRO ASSEMBLY OF HOMOPOLYMER AND CO-POLYMER FILAMENTS FROM INTERMEDIATE FILAMENT SUBUNITS OF MUSCLE AND FIBROBLASTIC CELLS. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 78(6), 3692-3696.

Academic Articles500

(2018). Revisiting the role of ABC transporters in multidrug-resistant cancer. NATURE REVIEWS CANCER. 18(7), 452-464.
(2018). The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding. JOURNAL OF BIOLOGICAL CHEMISTRY. 293(42), 16142-16159.
(2017). An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 37(6), 2062-2075.
(2017). Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity. JOURNAL OF BIOLOGICAL CHEMISTRY. 292(2), 446-461.
(2016). A Gene Expression Signature Associated with Overall Survival in Patients with Hepatocellular Carcinoma Suggests a New Treatment Strategy. MOLECULAR PHARMACOLOGY. 89(2), 263-272.

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Articles1

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