Seidman, Michael M., Ph.D.
individual record
Senior Investigator
Positions:
- Senior Investigator, Laboratory of Molecular Gerontology
overview
Dr. Michael Seidman received his Ph.D. in biochemistry from the University of California, Berkeley, in 1975. He did postdoctoral work at the NIH and at Princeton University. He worked at the NIH and in the biotechnology industry before assuming his present position in the Laboratory of Molecular Genetics, NIA.
selected publications
Academic Articles137
- (2020). FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links. NUCLEIC ACIDS RESEARCH. 48(16), 9161-9180.
- (2020). DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain. Nature Communications. 11(1),
- (2019). EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2. MOLECULAR CELL. 75(3), 605-+.
- (2019). Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy. CLINICAL CANCER RESEARCH. 25(18), 5584-5594.
- (2019). Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2. Cell Reports. 27(6), 1794-+.
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- (2018). R-loops cause genomic instability in T helper lymphocytes from patients with Wiskott-Aldrich syndrome. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 142(1), 219-234.
- (2017). Arsenite Binds to the RING Finger Domain of FANCL E3 Ubiquitin Ligase and Inhibits DNA Interstrand Crosslink Repair. ACS Chemical Biology. 12(7), 1858-1866.
- (2017). CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes. CANCER CELL. 31(5), 653-+.
- (2017). Fanconi Anemia: A DNA repair disorder characterized by accelerated decline of the hematopoietic stem cell compartment and other features of aging. AGEING RESEARCH REVIEWS. 33, 67-75.
- (2017). Mechanistic insights into how CMG helicase facilitates replication past DNA roadblocks. DNA REPAIR. 55, 76-82.
- (2017). Nuclear GIT2 Is an ATM Substrate and Promotes DNA Repair (vol 35, pg 1081, 2015). MOLECULAR AND CELLULAR BIOLOGY. 37(17),
- (2017). Single Molecule Analysis of Laser Localized Psoralen Adducts. Jove-Journal of Visualized Experiments. (122),
- (2016). Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer. CANCER CELL. 30(4), 637-650.
- (2016). FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks. NUCLEIC ACIDS RESEARCH. 44(7), 3219-3232.
- (2016). Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction. GENES & DEVELOPMENT. 30(6), 645-659.
- (2016). Single Molecule Analysis of Laser Localized Interstrand Crosslinks. Frontiers in Genetics. 7,
- (2015). CSB interacts with SNM1A and promotes DNA interstrand crosslink processing. NUCLEIC ACIDS RESEARCH. 43(1), 247-258.
- (2015). Catalytic Strand Separation by RECQ1 Is Required for RPA-Mediated Response to Replication Stress. CURRENT BIOLOGY. 25(21), 2830-2838.
- (2015). Contra lateral hearing loss after vestibular schwannoma excision: A rare complication of neurotologic surgery. ENT-EAR NOSE & THROAT JOURNAL. 94(1), 28-31.
- (2015). MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links. GENES & DEVELOPMENT. 29(18), 1955-1968.
- (2015). Nuclear GIT2 Is an ATM Substrate and Promotes DNA Repair. MOLECULAR AND CELLULAR BIOLOGY. 35(7), 1081-1096.
- (2015). UHRF1 Contributes to DNA Damage Repair as a Lesion Recognition Factor and Nuclease Scaffold. Cell Reports. 10(12), 1957-1966.