Hikosaka, Okihide, M.D., Ph.D.
individual record
Senior Investigator
Positions:
- Senior Investigator, Neuronal Networks Section
overview
Dr. Hikosaka received his M.D. and Ph.D. from University of Tokyo where he worked in the laboratory of Hiroshi Shimazu on the brainstem vestibulo-oculomotor system. He did postdoctoral research with Robert Wurtz at the Laboratory of Sensorimotor Research, NEI on the role of the substantia nigra pars reticulata in the control of saccadic eye movements. He became Assistant Professor at Toho University School of Medicine (Tokyo) in 1979, Full Professor at National Institute of Physiological Sciences (Okazaki) in 1988, and Full Professor at Juntendo University School of Medicine (Tokyo) in 1993. In 2002, he returned to the Laboratory of Sensorimotor Research, NEI as a Senior Investigator and Chief of the Section of Neuronal Networks. He was elected to the American Academy of Arts & Sciences in 2011. His main interest is the neural mechanisms of voluntary behavior. His laboratory studies the mechanisms of motivation, learning, skill, decision-making, attention, and oculomotor control.
selected publications
Academic Articles173
- (2019). Direct and indirect pathways for choosing objects and actions. EUROPEAN JOURNAL OF NEUROSCIENCE. 49(5), 637-645.
- (2019). Medial thalamus in the territory of oculomotor basal ganglia represents stable object value. EUROPEAN JOURNAL OF NEUROSCIENCE. 49(5), 672-686.
- (2019). Neuronal connections of direct and indirect pathways for stable value memory in caudal basal ganglia. EUROPEAN JOURNAL OF NEUROSCIENCE. 49(5), 712-725.
- (2019). The Caudal Part of Putamen Represents the Historical Object Value Information. JOURNAL OF NEUROSCIENCE. 39(9), 1709-1719.
- (2018). Amygdala activity for the modulation of goal-directed behavior in emotional contexts. PLOS BIOLOGY. 16(6),
- (2018). Parallel basal ganglia circuits for decision making. JOURNAL OF NEURAL TRANSMISSION. 125(3), 515-529.
- (2018). Prefrontal Cortex Represents Long-Term Memory of Object Values for Months. CURRENT BIOLOGY. 28(14), 2206-+.
- (2018). Temporal-prefrontal cortical network for discrimination of valuable objects in long-term memory. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 115(9), E2135-E2144.
- (2018). Visual Neurons in the Superior Colliculus Discriminate Many Objects by Their Historical Values. Frontiers in Neuroscience. 12,
- (2017). Indirect Pathway of Caudal Basal Ganglia for Rejection of Valueless Visual Objects. NEURON. 94(4), 920-+.
- (2017). To Wait or Not to Wait-Separate Mechanisms in the Oculomotor Circuit of Basal Ganglia. Frontiers in Neuroanatomy. 11,
- (2017). What do eye movements tell us about patients with neurological disorders? - An introduction to saccade recording in the clinical setting -. PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES. 93(10), 772-801.
- (2016). Ecological Origins of Object Salience: Reward, Uncertainty, Aversiveness, and Novelty. Frontiers in Neuroscience. 10,
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- (2015). Dopamine Neurons Encoding Long-Term Memory of Object Value for Habitual Behavior. CELL. 163(5), 1165-1175.
- (2015). Functional territories in primate substantia nigra pars reticulata separately signaling stable and flexible values. JOURNAL OF NEUROPHYSIOLOGY. 113(6), 1681-1696.
- (2015). Neurons in the Primate Medial Basal Forebrain Signal Combined Information about Reward Uncertainty, Value, and Punishment Anticipation. JOURNAL OF NEUROSCIENCE. 35(19), 7443-7459.
- (2015). Parallel basal ganglia circuits for voluntary and automatic behaviour to reach rewards. BRAIN. 138, 1776-1800.
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- (2014). Basal Ganglia Circuits for Reward Value-Guided Behavior. Annual Review of Neuroscience. 37, 289-+.
- (2014). PEDUNCULOPONTINE TEGMENTAL NUCLEUS NEURONS PROVIDE REWARD, SENSORIMOTOR, AND ALERTING SIGNALS TO MIDBRAIN DOPAMINE NEURONS. NEUROSCIENCE. 282, 139-155.
- (2014). Reward processing by the lateral habenula in normal and depressive behaviors. NATURE NEUROSCIENCE. 17(9), 1146-1152.
- (2014). Separate groups of dopamine neurons innervate caudate head and tail encoding flexible and stable value memories. Frontiers in Neuroanatomy. 8,
- (2013). Distinct Basal Ganglia Circuits Controlling Behaviors Guided by Flexible and Stable Values. NEURON. 79(5), 1001-1010.
- (2013). Diverse sources of reward value signals in the basal ganglia nuclei transmitted to the lateral habenula in the monkey. Frontiers in Human Neuroscience. 7,
- (2013). New perspectives on the pathophysiology of Parkinson's disease as assessed by saccade performance: A clinical review. CLINICAL NEUROPHYSIOLOGY. 124(8), 1491-1506.
- (2013). Reward Value-Contingent Changes of Visual Responses in the Primate Caudate Tail Associated with a Visuomotor Skill. JOURNAL OF NEUROSCIENCE. 33(27), 11227-11238.
- (2013). Selective and graded coding of reward uncertainty by neurons in the primate anterodorsal septal region. NATURE NEUROSCIENCE. 16(6), 756-+.
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- (2013). pyElectrode: An open-source tool using structural MRI for electrode positioning and neuron mapping. JOURNAL OF NEUROSCIENCE METHODS. 213(1), 123-131.
- (2012). Learning to represent reward structure: A key to adapting to complex environments. NEUROSCIENCE RESEARCH. 74(3-4), 177-183.
- (2012). Regionally Distinct Processing of Rewards and Punishments by the Primate Ventromedial Prefrontal Cortex. JOURNAL OF NEUROSCIENCE. 32(30), 10318-10330.
- (2012). Robust Representation of Stable Object Values in the Oculomotor Basal Ganglia. JOURNAL OF NEUROSCIENCE. 32(47), 16917-16932.
- (2012). The Primate Ventral Pallidum Encodes Expected Reward Value and Regulates Motor Action. NEURON. 76(4), 826-837.
- (2012). What and Where Information in the Caudate Tail Guides Saccades to Visual Objects. JOURNAL OF NEUROSCIENCE. 32(32), 11005-11016.
- (2011). Cortico-basal ganglia mechanisms for overcoming innate, habitual and motivational behaviors. EUROPEAN JOURNAL OF NEUROSCIENCE. 33(11), 2058-2069.
- (2011). Dopamine-mediated learning and switching in cortico-striatal circuit explain behavioral changes in reinforcement learning. Frontiers in Behavioral Neuroscience. 5,
- (2011). Initiation and inhibitory control of saccades with the progression of Parkinson's disease - Changes in three major drives converging on the superior colliculus. NEUROPSYCHOLOGIA. 49(7), 1794-1806.
- (2011). Lateral habenula neurons signal errors in the prediction of reward information. NATURE NEUROSCIENCE. 14(9), 1209-U149.
- (2011). Negative Reward Signals from the Lateral Habenula to Dopamine Neurons Are Mediated by Rostromedial Tegmental Nucleus in Primates. JOURNAL OF NEUROSCIENCE. 31(32), 11457-11471.
- (2010). A Pallidus-Habenula-Dopamine Pathway Signals Inferred Stimulus Values. JOURNAL OF NEUROPHYSIOLOGY. 104(2), 1068-1076.
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- (2010). Distinct Tonic and Phasic Anticipatory Activity in Lateral Habenula and Dopamine Neurons. NEURON. 67(1), 144-155.
- (2010). Dopamine in Motivational Control: Rewarding, Aversive, and Alerting. NEURON. 68(5), 815-834.
- (2010). Effects of STN stimulation on the initiation and inhibition of saccade in Parkinson disease. NEUROLOGY. 74(9), 743-748.
- (2010). Multiple Timescales of Memory in Lateral Habenula and Dopamine Neurons. NEURON. 67(3), 499-510.
- (2010). Switching from automatic to controlled behavior: cortico-basal ganglia mechanisms. TRENDS IN COGNITIVE SCIENCES. 14(4), 154-161.
- (2010). The habenula: from stress evasion to value-based decision-making. NATURE REVIEWS NEUROSCIENCE. 11(7), 503-513.
- (2009). Midbrain Dopamine Neurons Signal Preference for Advance Information about Upcoming Rewards. NEURON. 63(1), 119-126.