Steele-Mortimer, Olivia Ann, Ph.D.
individual record
Senior Investigator
Positions:
- Senior Investigator, Salmonella Host-Cell Interations Section
overview
Dr. Steele-Mortimer received her Ph.D. in cell biology from the European Molecular Biology Laboratory in 1994. From 1995 to 1999, she did postdoctoral research on Salmonella-host cell interactions in the laboratory of B. Brett Finlay at the University of British Columbia in Vancouver, followed by one year at Washington University, St. Louis, with Phillip D. Stahl. She came to NIH in 2001 and became a tenured senior investigator in 2007. Dr. Steele-Mortimer is an associate editor of Microbial Pathogenesis and is a member of the editorial board of Traffic.
selected publications
Articles1
Academic Articles45
- (2019). A role for the Salmonella Type III Secretion System 1 in bacterial adaptation to the cytosol of epithelial cells. MOLECULAR MICROBIOLOGY. 112(4), 1270-1283.
- (2017). A second wave of Salmonella T3SS1 activity prolongs the lifespan of infected epithelial cells. PLoS Pathogens. 13(4),
- (2017). Predictable, Tunable Protein Production in Salmonella for Studying Host-Pathogen Interactions. Frontiers in Cellular and Infection Microbiology. 7,
- (2017). Salmonella Meningitis Associated with Monocyte Infiltration in Mice. AMERICAN JOURNAL OF PATHOLOGY. 187(1), 187-199.
- (2016). Genetic Determinants of Salmonella enterica Serovar Typhimurium Proliferation in the Cytosol of Epithelial Cells. INFECTION AND IMMUNITY. 84(12), 3517-3526.
- (2015). Replication of Salmonella enterica Serovar Typhimurium in Human Monocyte-Derived Macrophages. INFECTION AND IMMUNITY. 83(7), 2661-2671.
- (2014). Host-microbe interactions: bacteria. War and peace: the fragile equilibrium between bacteria and host. CURRENT OPINION IN MICROBIOLOGY. 17, V-VII.
- (2014). Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens. Cell Host & Microbe. 16(2), 249-256.
- (2014). The Annexin A2/p11 complex is required for efficient invasion of Salmonella Typhimurium in epithelial cells. CELLULAR MICROBIOLOGY. 16(1), 64-77.
- (2014). Yersinia pestis survival and replication within human neutrophil phagosomes and uptake of infected neutrophils by macrophages. JOURNAL OF LEUKOCYTE BIOLOGY. 95(3), 389-398.
- (2011). Activation of Akt by the Bacterial Inositol Phosphatase, SopB, is Wortmannin Insensitive. PLoS One. 6(7),
- (2011). Coiled-coil domains enhance the membrane association of Salmonella type III effectors. CELLULAR MICROBIOLOGY. 13(10), 1497-1517.
- (2010). Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 107(41), 17733-17738.
- (2010). Induction of Salmonella pathogenicity island 1 under different growth conditions can affect Salmonella-host cell interactions in vitro. MICROBIOLOGY-SGM. 156, 1120-1133.
- (2009). Salmonella- the ultimate insider. Salmonella virulence factors that modulate intracellular survival. CELLULAR MICROBIOLOGY. 11(11), 1579-1586.
- (2009). Ubiquitination of the bacterial inositol phosphatase, SopB, regulates its biological activity at the plasma membrane. CELLULAR MICROBIOLOGY.
- (2008). Dynamic Behavior of Salmonella-Induced Membrane Tubules in Epithelial Cells. TRAFFIC. 9(12), 2117-2129.
- (2008). HilD-mediated transcriptional cross-talk between SPI-1 and SPI-2. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 105(38), 14591-14596.
- (2008). The Salmonella-containing vacuole - Moving with the times. CURRENT OPINION IN MICROBIOLOGY. 11(1), 38-45.
- (2007). Salmonella trafficking is defined by continuous dynamic interactions with the endolysosomal system. TRAFFIC. 8(3), 212-225.
- (2006). Structure-based mutagenesis of SigE verifies the importance of hydrophobic and electrostatic residues in type III chaperone function. MOLECULAR MICROBIOLOGY. 62(4), 928-940.
- (2006). The Salmonella effector protein PipB2 is a linker for kinesin-1. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 103(36), 13497-13502.
- (2006). The mechanism of Salmonella entry determines the vacuolar environment and intracellular gene expression. TRAFFIC. 7(1), 39-51.
- (2005). Chlamydial IFN-gamma immune evasion is linked to host infection tropism. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 102(30), 10658-10663.
- (2005). Cloning vectors and fluorescent proteins can significantly inhibit Salmonella enterica virulence in both epithelial cells and macrophages: Implications for bacterial pathogenesis studies. INFECTION AND IMMUNITY. 73(10), 7027-7031.
- (2005). The Salmonella SPI1 effector SopB stimulates nitric oxide production long after invasion. CELLULAR MICROBIOLOGY. 7(1), 105-113.
- (2005). The Salmonella effector PipB2 affects late endosome/lysosome distribution to mediate sif extension. MOLECULAR BIOLOGY OF THE CELL. 16(9), 4108-4123.
- (2005). The Salmonella effector protein SopB protects epithelial cells from apoptosis by sustained activation of Akt. JOURNAL OF BIOLOGICAL CHEMISTRY. 280(10), 9058-9064.
- (2005). Uptake and neuritic transport of scrapie prion protein coincident with infection of neuronal cells. JOURNAL OF NEUROSCIENCE. 25(21), 5207-5216.
- (2004). Modulation and utilization of host cell phosphoinositides by Salmonella spp.. INFECTION AND IMMUNITY. 72(8), 4331-4335.
- (2003). Salmonella type III effectors PipB and PipB2 are targeted to detergent-resistant microdomains on internal host cell membranes. MOLECULAR MICROBIOLOGY. 49(3), 685-704.
- (2002). Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages. CELL. 110(1), 119-131.
- (1990). FLOW CYTOMETRIC ANALYSIS OF VIRUS-INFECTED CELLS AND ITS POTENTIAL USE FOR SCREENING ANTIVIRAL AGENTS. JOURNAL OF VIROLOGICAL METHODS. 27(3), 241-252.