Cohen-Fix, Orna, Ph.D.
individual record
Senior Investigator
Positions:
- Senior Investigator, Cell Cycle Regulation and Nuclear Structure Section, Laboratory of Cell and Molecular Biology
overview
- Adjunct Professor, Johns Hopkins University, 2011–Present
- Director, the NIH/Johns Hopkins University Graduate Partnership Program, NIH, 2008–present
- Senior Investigator and Section Chief, NIDDK, NIH, 2005–Present
- Tenure-Track Investigator, NIDDK, NIH, 1998–2005
- Postdoctoral Fellow, The Carnegie Institution of Washington, 1994–1998
- Ph.D., Weizmann Institute of Science, 1994
- M.S., Weizmann Institute of Science, 1989
- B.A., Tel-Aviv University, 1986
selected publications
Academic Articles54
- (2020). C. elegans pronuclei fuse after fertilization through a novel membrane structure. JOURNAL OF CELL BIOLOGY. 219(2),
- (2019). Nuclear envelope expansion in budding yeast is independent of cell growth and does not determine nuclear volume. MOLECULAR BIOLOGY OF THE CELL. 30(1), 131-145.
- (2019). The Multiple Ways Nuclei Scale on a Multinucleated Muscle Cell Scale. DEVELOPMENTAL CELL. 49(1), 3-5.
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- (2017). Live-imaging analysis of germ cell proliferation in the C-elegans adult supports a stochastic model for stem cell proliferation. DEVELOPMENTAL BIOLOGY. 423(2), 93-100.
- (2016). Editorial overview: The cell nucleus: Plastic, elastic and fantastic. CURRENT OPINION IN CELL BIOLOGY. 40, IV-V.
- (2016). The Malleable Nature of the Budding Yeast Nuclear Envelope: Flares, Fusion, and Fenestrations. JOURNAL OF CELLULAR PHYSIOLOGY. 231(11), 2353-2360.
- (2015). Caenorhabditis elegans polo-like kinase PLK-1 is required for merging parental genomes into a single nucleus. MOLECULAR BIOLOGY OF THE CELL. 26(25), 4718-4735.
- (2014). Down-regulation of tricarboxylic acid (TCA) cycle genes blocks progression through the first mitotic division in Caenorhabditis elegans embryos. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 111(7), 2602-2607.
- (2014). Morphology and function of membrane-bound organelles. CURRENT OPINION IN CELL BIOLOGY. 26, 79-86.
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- (2014). The Yeast Polo Kinase Cdc5 Regulates the Shape of the Mitotic Nucleus. CURRENT BIOLOGY. 24(23), 2861-2867.
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- (2013). The dynamic nature of the nuclear envelope Lessons from closed mitosis. Nucleus. 4(4), 261-266.
- (2012). Shaping the nucleus: Factors and forces. JOURNAL OF CELLULAR BIOCHEMISTRY. 113(9), 2813-2821.
- (2012). Sm protein down-regulation leads to defects in nuclear pore complex disassembly and distribution in C-elegans embryoss. DEVELOPMENTAL BIOLOGY. 365(2), 445-457.
- (2012). The Budding Yeast Nuclear Envelope Adjacent to the Nucleolus Serves as a Membrane Sink during Mitotic Delay. CURRENT BIOLOGY. 22(12), 1128-1133.
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- (2010). Changes in the Nuclear Envelope Environment Affect Spindle Pole Body Duplication in Saccharomyces cerevisiae. GENETICS. 186(3), 867-U191.
- (2010). Vesicle trafficking maintains nuclear shape in Saccharomyces cerevisiae during membrane proliferation. JOURNAL OF CELL BIOLOGY. 191(6), 1079-1088.
- (2009). Inactivation of the C-elegans lipin homolog leads to ER disorganization and to defects in the breakdown and reassembly of the nuclear envelope. JOURNAL OF CELL SCIENCE. 122(12), 1970-1978.
- (2009). Sizing up the nucleus: nuclear shape, size and nuclear-envelope assembly. JOURNAL OF CELL SCIENCE. 122(10), 1477-1486.
- (2008). The Endoplasmic Reticulum Takes Center Stage in Cell Cycle Regulation. Science Signaling. 1(3),
- (2007). Falling off the academic bandwagon - Women are more likely to quit at the postdoc to principal investigator transition. EMBO REPORTS. 8(11), 977-981.
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- (2006). Before and after the spindle assembly checkpoint - An APC/C point of view. CELL CYCLE. 5(18), 2168-2171.
- (2006). Yeast nuclear envelope subdomains with distinct abilities to resist membrane expansion. MOLECULAR BIOLOGY OF THE CELL. 17(4), 1768-1778.
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- (2004). Uncovering novel cell cycle players through the inactivation of securin in budding yeast. GENETICS. 168(3), 1763-1771.
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- (2003). Meiosis: Polo, FEAR and the art of dividing reductionally. CURRENT BIOLOGY. 13(15), R603-R605.
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- (2003). The role of Cdh1p in maintaining genomic stability in budding yeast. GENETICS. 165(2), 489-503.
- (2003). Two distinct pathways for inhibiting Pds1 ubiquitination in response to DNA damage. JOURNAL OF BIOLOGICAL CHEMISTRY. 278(45), 45027-45033.
- (2002). Chromosome cohesion: ring around the sisters?. TRENDS IN BIOCHEMICAL SCIENCES. 27(10), 492-495.
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- (2002). Phosphorylation of the mitotic regulator Pds1/securin by Cdc28 is required for efficient nuclear localization of Esp1/separase. GENES & DEVELOPMENT. 16(11), 1371-1382.
- (2002). Separase: a conserved protease separating more than just sisters. TRENDS IN CELL BIOLOGY. 12(1), 1-3.
- (2001). The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner. CURRENT BIOLOGY. 11(17), 1347-1352.
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- (2000). Sister chromatid separation: Falling apart at the seams. CURRENT BIOLOGY. 10(22), R816-R819.
- (1999). Pds1p of budding yeast has dual roles: inhibition of anaphase initiation and regulation of mitotic exit. GENES & DEVELOPMENT. 13(15), 1950-1959.
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- (1997). The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 94(26), 14361-14366.
- (1997). The metaphase-to-anaphase transition: avoiding a mid-life crisis. CURRENT OPINION IN CELL BIOLOGY. 9(6), 800-806.
- (1996). Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. GENES & DEVELOPMENT. 10(24), 3081-3093.
- (1996). Reconstitution of repair-gap UV mutagenesis with purified proteins from Escherichia coli: A role for DNA polymerases III and II. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 93(4), 1376-1380.
- (1995). DEAMINATION OF CYTOSINE-CONTAINING PYRIMIDINE PHOTODIMERS IN UV-IRRADIATED DNA - SIGNIFICANCE FOR UV-LIGHT MUTAGENESIS. JOURNAL OF BIOLOGICAL CHEMISTRY. 270(41), 24174-24179.
- (1994). IN-VITRO UV MUTAGENESIS ASSOCIATED WITH NUCLEOTIDE EXCISION-REPAIR GAPS IN ESCHERICHIA-COLI. JOURNAL OF BIOLOGICAL CHEMISTRY. 269(7), 4953-4958.
- (1993). REPLICATION OF DAMAGED DNA AND THE MOLECULAR MECHANISM OF ULTRAVIOLET-LIGHT MUTAGENESIS. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. 28(6), 465-513.
- (1992). BIOCHEMICAL-ANALYSIS OF UV MUTAGENESIS IN ESCHERICHIA-COLI BY USING A CELL-FREE REACTION COUPLED TO A BIOASSAY - IDENTIFICATION OF A DNA REPAIR-DEPENDENT, REPLICATION-INDEPENDENT PATHWAY. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 89(8), 3300-3304.