Sieving, Paul Albert, M.D., Ph.D.
individual record
Senior Investigator
Positions:
- Senior Investigator, Section for Translational Research on Retinal and Macular Degeneration
overview
Paul Sieving received his M.D. from the University of Illinois in 1978 and trained in ophthalmology at that institution between 1978 and 1982. He earned a Ph.D. in bioengineering from the University of Illinois in 1981. He was a faculty member at the University of Michigan Medical School for 17 years and moved to NIH in 2001. He combines laboratory research with clinical patient studies of genetic retinal neurodegenerative diseases. He is a member of the Institute of Medicine and currently serves as director of the National Eye Institute.
selected publications
Articles1
- (2020). "There Are Hills and Valleys": Experiences of Parenting a Son With X-Linked Retinoschisis. AMERICAN JOURNAL OF OPHTHALMOLOGY. 212, 98-104.
Academic Articles218
- (2020). NEI-Supported Age-RelatedMacular Degeneration Research: Past, Present, and Future. Translational Vision Science & Technology. 9(7),
- (2020). "There Are Hills and Valleys": Experiences of Parenting a Son With X-Linked Retinoschisis. AMERICAN JOURNAL OF OPHTHALMOLOGY. 212, 98-104.
- (2020). Improved Ocular Tissue Models and Eye-On-A-Chip Technologies Will Facilitate Ophthalmic Drug Development. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS. 36(1), 25-29.
- (2019). AAVrh-10 transduces outer retinal cells in rodents and rabbits following intravitreal administration. GENE THERAPY. 26(9), 386-398.
- (2019). Cone ERG Changes During Light Adaptation in Two All-Cone Mutant Mice: Implications for Rod-Cone Pathway Interactions. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 60(10), 3680-3688.
- (2019). Cryo-EM of retinoschisin branched networks suggests an intercellular adhesive scaffold in the retina. JOURNAL OF CELL BIOLOGY. 218(3), 1027-1038.
- (2019). Motivations and Decision Making Processes of Men With X-linked Retinoschisis Considering Participation in an Ocular Gene Therapy Trial. AMERICAN JOURNAL OF OPHTHALMOLOGY. 204, 90-96.
- (2019). The NIH Blueprint for Neuroscience Research Seeks Community Input on Future Neuroscience Investments. JOURNAL OF NEUROSCIENCE. 39(5), 774-775.
- (2019). Trans-ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Gene Transduction after Intravitreal Vector Administration. Molecular Therapy-Methods & Clinical Development. 13, 77-85.
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- (2018). Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy. JOURNAL OF CLINICAL INVESTIGATION. 128(12), 5663-5675.
- (2018). Analysis of Anatomic and Functional Measures in X-Linked Retinoschisis. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 59(7), 2841-2847.
- (2018). IFT88 mutations identified in individuals with non-syndromic recessive retinal degeneration result in abnormal ciliogenesis. HUMAN GENETICS. 137(6-7), 447-458.
- (2018). Identification of Novel Deletions as the Underlying Cause of Retinal Degeneration in Two Pedigrees. Advances in Experimental Medicine and Biology. 1074, 229-236.
- (2018). Investigation of the effect of dietary docosahexaenoic acid (DHA) supplementation on macular function in subjects with autosomal recessive Stargardt macular dystrophy. OPHTHALMIC GENETICS. 39(4), 477-486.
- (2018). Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa. PLoS Genetics. 14(8),
- (2018). Neuroethics for the National Institutes of Health BRAIN Initiative. JOURNAL OF NEUROSCIENCE. 38(50), 10583-10585.
- (2018). Optical Coherence Tomography Minimum Intensity as an Objective Measure for the Detection of Hydroxychloroquine Toxicity. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 59(5), 1953-1963.
- (2018). Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery. MOLECULAR THERAPY. 26(9), 2282-2294.
- (2018). The National Eye Institute's Commitment to Career Development of Clinician-Scientists. JAMA Ophthalmology. 136(12), 1340-1341.
- (2018). Translational Retinal Research and Therapies. Translational Vision Science & Technology. 7(5),
- (2017). Homozygosity Mapping and Genetic Analysis of Autosomal Recessive Retinal Dystrophies in 144 Consanguineous Pakistani Families. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 58(4), 2218-2238.
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