- Senior Investigator, Signal Transduction Laboratory / Post-Transcriptional Gene Expression Group
Dr. Blackshear obtained his DPhil degree in biochemistry from the University of Oxford in 1974, and his MD from Harvard Medical School in 1977. He did his internship and residency in internal medicine, and fellowship in endocrinology at the Massachusetts General Hospital and Harvard Medical School, and remained there as an Assistant Professor of Medicine. In 1984, he moved to Duke University, where he was an Investigator of the Howard Hughes Medical Institute and, ultimately, Professor of Medicine and of Biochemistry. He moved to the NIEHS as Clinical Director and Senior Investigator in 1997, and became acting Scientific Director in 2007. He is currently a Senior Investigator in the Laboratory of Signal Transduction, NIEHS.
- (2020). Tristetraprolin Overexpression in Non-hematopoietic Cells Protects Against Acute Lung Injury in Mice. Frontiers in Immunology. 11,
- (2020). Tristetraprolin Regulates T(H)17 Cell Function and Ameliorates DSS-Induced Colitis in Mice. Frontiers in Immunology. 11,
- (2020). Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages. JOURNAL OF BIOLOGICAL CHEMISTRY. 295(14), 4661-4672.
- (2019). Importance of the Conserved Carboxyl-Terminal CNOT1 Binding Domain to Tristetraprolin Activity In Vivo. MOLECULAR AND CELLULAR BIOLOGY. 39(13),