Gu, Shuo, Ph.D.
individual record
Stadtman Investigator
Positions:
- Stadtman Investigator, Gene Regulation and Chromosome Biology Laboratory
overview
Shuo Gu received his B.A. in Tsinghua University, CHINA in 1998. He completed his Ph.D. training in the laboratory of Dr. John Rossi at Beckman Research Institute, City of Hope, Los Angeles. Shuo Gu undertook his postdoctoral training in the laboratory of Dr. Mark Kay at Stanford University Medical School, Palo Alto. Both his Ph.D. and postdoctoral research focused on the mechanisms of RNA interference and microRNA pathways, and their applications in gene therapy. He Joined the Gene Regulation and Chromosome Biology Laboratory in 2013.
selected publications
Academic Articles9
- (2020). Novel, abundant Drosha isoforms are deficient in miRNA processing in cancer cells. RNA Biology. 17(11), 1603-1612.
- (2019). KSHV RNA-binding protein ORF57 inhibits P-body formation to promote viral multiplication by interaction with Ago2 and GW182. NUCLEIC ACIDS RESEARCH. 47(17), 9368-9385.
- (2016). Cytoplasmic Drosha activity generated by alternative splicing. NUCLEIC ACIDS RESEARCH. 44(21), 10454-10466.
- (2012). Expression determinants of mammalian argonaute proteins in mediating gene silencing. NUCLEIC ACIDS RESEARCH. 40(8), 3704-3713.
- (2012). Slicing-Independent RISC Activation Requires the Argonaute PAZ Domain. CURRENT BIOLOGY. 22(16), 1536-1542.
- (2012). The Loop Position of shRNAs and Pre-miRNAs Is Critical for the Accuracy of Dicer Processing In Vivo. CELL. 151(4), 900-911.
- (2011). Thermodynamic stability of small hairpin RNAs highly influences the loading process of different mammalian Argonautes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 108(22), 9208-9213.
- (2010). Argonaute proteins are key determinants of RNAi efficacy, toxicity, and persistence in the adult mouse liver. JOURNAL OF CLINICAL INVESTIGATION. 120(9), 3106-3119.