Scholars

Senior Investigator

Positions:

Senior Investigator, Laboratory of Muscle Stem Cells and Gene Regulation

Research Areas:

Research & Experimental Medicine, Developmental Biology, Genetics & Heredity, Science & Technology - Other Topics, Oncology, Biochemistry & Molecular Biology, Evolutionary Biology, Pharmacology & Pharmacy, Cell Biology, Life Sciences & Biomedicine - Other Topics, Immunology, Neurosciences & Neurology, Pathology

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overview

Dr. Sartorelli obtained his degree in Medicine from the University of Brescia, Italy and did a Residency in Oncology at the University of Milan, Italy. He joined the Genetics Department and the Department of Medicine of the Stanford University for his postdoctoral education.
In 1990, Dr.Sartorelli was appointed Assistant Professor in the Department of Chemistry at the University of Brescia, School of Medicine. In 1993, he joined the Department of Biochemistry and Molecular Biology of the Keck School of Medicine, University of Southern California as an Assistant Professor and was recruited in 1999 at the National Institutes of Health to head the Muscle Gene Expression Group within the Laboratory of Muscle Biology of the Intramural Program at the National Institute of Arthritis and Musculoskeletal and Skin Diseases.

selected publications

Academic Articles92

(2020). Enhancer RNAs are an important regulatory layer of the epigenome. NATURE STRUCTURAL & MOLECULAR BIOLOGY. 27(6), 521-528.
(2019). Single cell analysis of adult mouse skeletal muscle stem cells in homeostatic and regenerative conditions. DEVELOPMENT. 146(12),
(2019). Single cell analysis of adult mouse skeletal muscle stem cells in homeostatic and regenerative conditions (vol 146, dev174177, 2019). DEVELOPMENT. 146(13),
(2019). miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8(+) T cell fate. Nature Communications. 10,
(2018). A Muscle-Specific Enhancer RNA Mediates Cohesin Recruitment and Regulates Transcription In trans. MOLECULAR CELL. 71(1), 129-+.
(2018). ATP Citrate Lyase: A New Player Linking Skeletal Muscle Metabolism and Epigenetics. TRENDS IN ENDOCRINOLOGY AND METABOLISM. 29(4), 202-204.
(2018). Argonaute-miRNA Complexes Silence Target mRNAs in the Nucleus of Mammalian Stem Cells. MOLECULAR CELL. 71(6), 1040-+.
(2018). Identification of Skeletal Muscle Satellite Cells by Immunofluorescence with Pax7 and Laminin Antibodies. Jove-Journal of Visualized Experiments. (134),
(2018). Shaping Gene Expression by Landscaping Chromatin Architecture: Lessons from a Master. MOLECULAR CELL. 71(3), 375-388.
(2017). Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival. Nature Communications. 8,
(2017). Gene Resistance to Transcriptional Reprogramming following Nuclear Transfer Is Directly Mediated by Multiple Chromatin-Repressive Pathways. MOLECULAR CELL. 65(5), 873-+.
(2017). Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells (vol 17, pg 1369, 2016). Cell Reports. 18(1), 297-297.
(2017). Specific Sirt1 Activator-mediated Improvement in Glucose Homeostasis Requires Sirt1-Independent Activation of AMPK. EBioMedicine. 18, 128-138.
(2017). The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins. MOLECULAR CELL. 68(2), 398-+.
(2016). Laminopathies disrupt epigenomic developmental programs and cell fate. Science Translational Medicine. 8(335),
(2016). MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-kappa B. Cell Reports. 17(2), 514-526.
(2016). Polycomb Ezh2 controls the fate of GABAergic neurons in the embryonic cerebellum. DEVELOPMENT. 143(11), 1971-1980.
(2016). Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells. Cell Reports. 17(5), 1369-1382.
(2016). S6K1ing to ResTOR Adipogenesis with Polycomb. MOLECULAR CELL. 62(3), 325-326.
(2016). S6K1ing to ResTOR Adipogenesis with Polycomb (vol 62, pg 325, 2016). MOLECULAR CELL. 64(4), 850-850.
(2016). The Histone Variant MacroH2A1.2 Is Necessary for the Activation of Muscle Enhancers and Recruitment of the Transcription Factor Pbx1. Cell Reports. 14(5), 1156-1168.
(2015). EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion. Scientific Reports. 5,
(2015). IL-6 Blockade as a Therapeutic Approach for Duchenne Muscular Dystrophy. EBioMedicine. 2(4), 274-275.
(2015). Metabolic Reprogramming of Stem Cell Epigenetics. Cell Stem Cell. 17(6), 651-662.
(2015). Super-enhancers delineate disease-associated regulatory nodes in T cells. NATURE. 520(7548), 558-+.
(2015). The NAD(+)-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells. Cell Stem Cell. 16(2), 171-183.
(2014). An evolutionarily biased distribution of miRNA sites toward regulatory genes with high promoter-driven intrinsic transcriptional noise. BMC EVOLUTIONARY BIOLOGY. 14,
(2014). Gcn5 and PCAF Regulate PPAR gamma and Prdm16 Expression To Facilitate Brown Adipogenesis. MOLECULAR AND CELLULAR BIOLOGY. 34(19), 3746-3753.
(2014). The emerging roles of eRNAs in transcriptional regulatory networks. RNA Biology. 11(2), 106-110.
(2013). A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. CELLULAR AND MOLECULAR LIFE SCIENCES. 70(11), 2015-2029.
(2013). BACH2 represses effector programs to stabilize T-reg-mediated immune homeostasis. NATURE. 498(7455), 506-+.
(2013). Essential Role of SIRT1 Signaling in the Nucleus Accumbens in Cocaine and Morphine Action. JOURNAL OF NEUROSCIENCE. 33(41), 16088-16098.
(2013). H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation. eLife. 2,
(2013). Interactome Maps of Mouse Gene Regulatory Domains Reveal Basic Principles of Transcriptional Regulation. CELL. 155(7), 1507-1520.
(2013). The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis. EMBO JOURNAL. 32(8), 1075-1086.
(2013). The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy. GENES & DEVELOPMENT. 27(11), 1299-1312.
(2013). Transcription factors and CD4 T cells seeking identity: masters, minions, setters and spikers. IMMUNOLOGY. 139(3), 294-298.
(2013). eRNAs Promote Transcription by Establishing Chromatin Accessibility at Defined Genomic Loci. MOLECULAR CELL. 51(5), 606-617.
(2012). Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 109(3), 841-846.
(2012). Polycomb Protein Ezh1 Promotes RNA Polymerase II Elongation. MOLECULAR CELL. 45(2), 255-262.
(2012). STATs Shape the Active Enhancer Landscape of T Cell Populations. CELL. 151(5), 981-993.
(2011). Decreased microRNA-214 levels in breast cancer cells coincides with increased cell proliferation, invasion and accumulation of the Polycomb Ezh2 methyltransferase. CARCINOGENESIS. 32(11), 1607-1614.
(2011). Phosphoryl-EZH-ion. Cell Stem Cell. 8(3), 262-265.
(2011). Polycomb EZH2 controls self-renewal and safeguards the transcriptional identity of skeletal muscle stem cells. GENES & DEVELOPMENT. 25(8), 789-794.
(2011). SCULPTING CHROMATIN BEYOND THE DOUBLE HELIX: EPIGENETIC CONTROL OF SKELETAL MYOGENESIS. Current Topics in Developmental Biology. 96, 57-83.
(2011). Who Needs Microtubules? Myogenic Reorganization of MTOC, Golgi Complex and ER Exit Sites Persists Despite Lack of Normal Microtubule Tracks. PLoS One. 6(12),
(2010). Dietary Restriction: Standing Up for Sirtuins. SCIENCE. 329(5995), 1012-1013.
(2010). HDACs and sirtuins: Targets for new pharmacological interventions in human diseases. PHARMACOLOGICAL RESEARCH. 62(1), 1-2.
(2010). MicroRNA-214 and polycomb group proteins A regulatory circuit controlling differentiation and cell fate decisions. CELL CYCLE. 9(8), 1445-1446.
(2010). Myc-Nick: The Force Behind c-Myc. Science Signaling. 3(152),

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Academic Articles92