Pastan, Ira, M.D.
individual record
NIH Distinguished Investigator
Positions:
- NIH Distinguished Investigator, Laboratory of Molecular Biology
Research Areas:
Research & Experimental Medicine,
Engineering,
Genetics & Heredity,
Food Science & Technology,
Rheumatology,
Science & Technology - Other Topics,
Cardiovascular System & Cardiology,
Biophysics,
Pharmacology & Pharmacy,
Radiology, Nuclear Medicine & Medical Imaging,
Pediatrics,
Anatomy & Morphology,
Reproductive Biology,
Endocrinology & Metabolism,
Biochemistry & Molecular Biology,
Oncology,
Materials Science,
Microbiology,
Respiratory System,
Cell Biology,
Chemistry,
Obstetrics & Gynecology,
Hematology,
Biotechnology & Applied Microbiology,
Transplantation,
Urology & Nephrology,
Physiology,
Immunology,
Neurosciences & Neurology,
Virology,
Medical Laboratory Technology,
Parasitology,
Pathology,
Toxicology
Research Areas:
Research & Experimental Medicine,
Engineering,
Genetics & Heredity,
Food Science & Technology,
Rheumatology,
Science & Technology - Other Topics,
Cardiovascular System & Cardiology,
Biophysics,
Pharmacology & Pharmacy,
Radiology, Nuclear Medicine & Medical Imaging,
Pediatrics,
Anatomy & Morphology,
Reproductive Biology,
Endocrinology & Metabolism,
Biochemistry & Molecular Biology,
Oncology,
Materials Science,
Microbiology,
Respiratory System,
Cell Biology,
Chemistry,
Obstetrics & Gynecology,
Hematology,
Biotechnology & Applied Microbiology,
Transplantation,
Urology & Nephrology,
Physiology,
Immunology,
Neurosciences & Neurology,
Virology,
Medical Laboratory Technology,
Parasitology,
Pathology,
Toxicology
overview
Dr. Pastan is co-chief of the Laboratory of Molecular Biology, Center for Cancer Research. He obtained his M.D. from Tufts University, received his medical training at Yale University and research training at the NIH. He established the Laboratory of Molecular Biology in 1970.
selected publications
Articles1
- (2020). Enhanced efficacy of mesothelin-targeted immunotoxin LMB-100 and anti-PD-1 antibody in patients with mesothelioma and mouse tumor models. Science Translational Medicine. 12(550),
Academic Articles1201
- (2020). Phase 1 study of the immunotoxin LMB-100 in patients with mesothelioma and other solid tumors expressing mesothelin. CANCER. 126(22), 4936-4947.
- (2020). Enhanced efficacy of mesothelin-targeted immunotoxin LMB-100 and anti-PD-1 antibody in patients with mesothelioma and mouse tumor models. Science Translational Medicine. 12(550),
- (2020). Population pharmacokinetics, efficacy, and safety of moxetumomab pasudotox in patients with relapsed or refractory hairy cell leukaemia. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 86(7), 1367-1376.
- (2020). Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with Nab-Paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma. CLINICAL CANCER RESEARCH. 26(4), 828-836.
Research Areas:
Research & Experimental Medicine,
Engineering,
Genetics & Heredity,
Food Science & Technology,
Rheumatology,
Science & Technology - Other Topics,
Cardiovascular System & Cardiology,
Biophysics,
Pharmacology & Pharmacy,
Radiology, Nuclear Medicine & Medical Imaging,
Pediatrics,
Anatomy & Morphology,
Reproductive Biology,
Endocrinology & Metabolism,
Biochemistry & Molecular Biology,
Oncology,
Materials Science,
Microbiology,
Respiratory System,
Cell Biology,
Chemistry,
Obstetrics & Gynecology,
Hematology,
Biotechnology & Applied Microbiology,
Transplantation,
Urology & Nephrology,
Physiology,
Immunology,
Neurosciences & Neurology,
Virology,
Medical Laboratory Technology,
Parasitology,
Pathology,
Toxicology
Research Areas:
Research & Experimental Medicine,
Engineering,
Genetics & Heredity,
Food Science & Technology,
Rheumatology,
Science & Technology - Other Topics,
Cardiovascular System & Cardiology,
Biophysics,
Pharmacology & Pharmacy,
Radiology, Nuclear Medicine & Medical Imaging,
Pediatrics,
Anatomy & Morphology,
Reproductive Biology,
Endocrinology & Metabolism,
Biochemistry & Molecular Biology,
Oncology,
Materials Science,
Microbiology,
Respiratory System,
Cell Biology,
Chemistry,
Obstetrics & Gynecology,
Hematology,
Biotechnology & Applied Microbiology,
Transplantation,
Urology & Nephrology,
Physiology,
Immunology,
Neurosciences & Neurology,
Virology,
Medical Laboratory Technology,
Parasitology,
Pathology,
Toxicology